MODA Drugs (1)

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Author:
yl456
ID:
180169
Filename:
MODA Drugs (1)
Updated:
2013-03-26 17:18:53
Tags:
Receptors Ion Channels
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Description:
Mechanism and effect
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  1. Pertussis toxin
    Causes ADP-ribosylation of αi subunit of G protein, preventing activation of Gi when stimulated
  2. Lidocaine
    • Local anaesthetic
    • Binds to and stabilises inactivated state of Na+ channels
    • Use and voltage dependence
  3. Benzocaine
    • Local anaesthetic
    • Blocks Na+ channels independent of pH
  4. Quinidine
    • Slow in, slow out LA
    • Use dependence at low rates of stimulation
  5. Tetrodotoxin
    • Blocks Na+ channels from the outside
    • Has guanidinium group
  6. Bay K 8644
    • Calcium agonist
    • Type of DHP
  7. Nifedipine
    • Calcium antagonist
    • Type of DHP
  8. Verapamil
    Ca2+ channel blocker
  9. Diltiazem
    Ca2+ channel blocker
  10. Glibenclamide
    • Orally acting hypoglycaemic agent
    • Closes KATP channel by acting on SUR
    • Stimulates insulin release
    • Treatment of Type II diabetes
  11. α-bungarotoxin
    • Nicotinic Ach receptor antagonist at nmj
    • Snake venom
    • Causes paralysis and respiratory failure
  12. Cholera Toxin
    • AB toxin
    • ADP-ribosylates the Gαi subunit, so unable to inhibit adenylyl cyclase production of cAMP
  13. Ethinylestradiol
    • Used in contraceptive pills
    • Natural form of oestrogen
  14. Minoxidil
    • NO agonist
    • Potassium channel opener
    • Used for hypertension
    • Promotes hair regrowth
  15. Nicorandil
    • Increases formation of cyclic GMP
    • K+ATP channel opener
    • Vasodilator
    • Treats angina
  16. Norethisterone
    • Used in contraceptive pill
    • Progestogen
  17. Prednisolone
    • Synthetic glucocorticoid receptor agonist
    • Irreversibly binds
  18. Tamoxifen
    • Oestrogen receptor antagonist in breast tissues
    • Agonist in others
    • Therapy for breast cancer
  19. Tyrphostins
    • Tyrosine-kinase inhibitor
    • Inhibits EGFR
  20. Adenosine
    • purine nucleoside
    • inhibitory neurotransmitter
    • Receptors are 7 transmembrane spanning G-protein coupled receptors
  21. Atropine
    smooth muscle muscarinic receptor antagonist
  22. Benzylcholine Mustard
    irreversibly alkylates the muscarinic receptor
  23. d-Tubocurarine
    skeletal muscle nicotinic receptor antagonist
  24. Isoprenaline
    β-adrenoceptor agonist
  25. Spironolactone
    Aldosterone receptor antagonist

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