How do: botox, succinylcholine, and myasthenia gravis affect the NMJ?
botox: prevents the ACh vesicle from fusing with the presynaptic membrane, thus preventing its release.
succinylcholine: ACh receptor agonist (i.e. it binds to the same receptors, causing them to open and in this case STAY OPEN), prevent any further action potentials
myasthenia gravis: autoimmune condition where antibodies bind to the ACh receptors. This prevents the ACh from binding, and also causes the destruction of the ACh receptors.