What are the effects of high-protein meal vs starvation?
Which will have AA degradation? Ammonia formation? AA synthesis?
What is the effect of increased protein on glutamate production for ALT?
Starvation --> low ATP:ADP and low GTP:GDP, so need high AA degradation to get energy production from C skeletons, thus increased synthesis of a-ketoglutarate for TCA cycle or for GNG.
Also get amino acid degradation and ammonia production. In liver, rxn proceeds in direction of AA degradation and formation of ammonia to get rid of excess protein. BUT CAN ALSO GET AA SYNTHESIS FROM CORRESPONDING A-KETO ACIDS.
Increased protein --> increased glutamate