SA Med, Q2, II
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SA Med, Q2, II
SA Med Q2 II
SA Med, Q2, II
What is the hallmark of glomerular disease?
protienuria (with an INACTIVE sediment)
what are the 2 types of glomerular dz in domestic animals?
what is the most common reason to see proteinuria?
lower urinary tract (stones, infection, etc) --> see protein along with active sediment
why are proteins not seen in urine in health?
large molecules, negatively charged so repelled by negative basement membrane; tubular reabsorption/catabolism
what are classical signs of nephrotic syndrome? 4
what produces mesangial matrix and is phagocytic/clears residues, therefore may play major role in mediating injury?
what is role of microfilaments found on mesangial cells?
respond to vasoactive substances like angiotensin II --> alter surface area of glomerulus available for filtration
What type of injury underlies most cases of glomerulonephritis?
immunologic injury (Ab-Ag complexes from pyometra, HW, SLE, adenovirus 1, chronic infections, neoplasia, IDIOPATHIC mostly)
What are some causes of immune complex formation in glomerulus of cats? 4
What breeds get membranoproliferative GN?
Bermese Mtn dog
What breeds get basement membrane disorders?
English Cocker Spaniel
What group of disease is characterized by extracellular deposition of protein subunits that form beta pleated sheets? what are characteristics when stained with H/E or congo red?
amyloidosis (homogenous eosinophilic with H/E stain; green birefringence w/congo red)
Is most amyloidosis systemic or localized?
most commonly systemic --> familial or idiopathic (or assoc.w/neoplasia or chronic disease)
What breeds are associated with familial reactive systemic amyloidosis?
shar pei, beagle, english foxhound
abyssinian, siamese, oriental short hair
What is usually the reason amyloidosis is discovered in a patient?
deposits are widespread but clinical signs relate to kidney involvement/renal failure
**exception when severe liver involvement in shar pei, siamese, and oriental SH get hemoabdomen
glomerulus v. medulla: where does amyloid deposit in the dog .v the cat? what are associated signs based on where deposits are?
: more in glomerulus --> proteinuria
cat (and shar pei)
: more in medulla --> isosthenuria/azotemia
If there is amyloid only in the medulla, will biopsy find this?
no, wedge or true cut only samples cortex/glomerulus
what is mean age of amyloidosis in shar pei? is the relationship familial or breed related?
4 yrs; male and female
black and fawn
Are amyloid signs in Shar peis usually chronic or acute signs? What is "shar pei fever"?
: recurrent acute self-limiting fever and tibiotarsal jt swelling that often resolves on its own
What are clinical findings of abyssinian cats with amyloidosis? 6
small irregular kidneys
what are lab findings for amyloidosis in abyssinian cats? 6
100% of affected cats w/amyloidosis have medullary or glomerulus involvement?
medullary - separates tubular cells from basement membrane
(75% have glomerular)
What is signalment for glomerular disease?
no gender predilection (cats w/GN usu. male)
any breed w/some familial syndromes