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what does the thymus look like? Where is it located?
Pink gland, behind sternum wall
State the process of T cell production. 3 steps.
- 1. Bone marrow produces lymphoid stem cells
- 2. Some LSC's migrate from bone to thymus
- 3. LSC's interact with thymosins creating mature T cells
Name 6 characteristics of the spleen
1. filters blood 2. removes abnormal cells, aged RBC's 3. produces lymphocytes 4. produces RBC's in fetus 5. Stores Iron from recycles RBC's 6. Stores RBC's then releases into blood
How does the spleen release RBC's?
(+)SNS to (+) spleen then contracts and releases
Is there nuerointervation of the spleen?
Describe the splenic blood flow. 8 steps
In red pulp. 1. Enters in splenic artery 2. to sinosuidal capillaries 3. blood goes into reticular fibers (make red pulp) 4. blood from red pulp enters venous sinusoids 5. macrophages engulf damaged/infected cells 6. blood reenters capillaries 7. enters small veins 8. exits out splenic vein
Where are the germinal centers located? What do they do?
White pulp. They produce lymphocytes that are released into the blood or remain in spleen.
What does the white pulp resemble? What is it surrounded by?
resemble lymphoid nodules. surrounded by small arteries.
define venous sinusoid
small vessels lined by macrophages
Name 1st line of defense. Specific or non-specific?
Barriers: skin and mucous membranes. NONSPECIFIC
Name 2nd line of defense. Specific or nonspecific?
- NONSPECIFIC Internal Defenses:
- Phagocytosis, NK cells, Inflammation, Fever
What line of defense would interferons fall into?