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Infection of B-ells with EBV through the CD21 protein
AD or AR?
- Bilobed, unsegmented neutrophi nuclei
- Normal neutrophil function
Acquired Pelger-Huet anomaly is seen in
Myelodysplasia or myeloid leukemia
Light blue cytoplasmic inclusions
RNA remnants or rER
Observed in infections and inflammatory states
Neutrophil nuclear hypersegmentation:
> 5 lobes
- Inherited Deficiency
Granulocyte transfusion (severely neutropenic pats with fever or infection unresponsive to antibiotics or antifungal agents)
Myeloproliferative Neoplasms (Chronic Myeloproliferative Disorders)
- CML (Chronic Myelogenous Leukemia)
- PV (Polycythemia Vera)
- ET (Essential Thrombocythemia)
- Primary Myelofibrosis
3 Stages of CML
- Chronic Phase
- Accelerated Phase
- Blast Phase
Philadelphia chromsome found in?
How do you differentiate CML from Leukemoid rxn?
Which one has more leukocyte alkaline.
- CML has basophilia, eosinophilia, and nucleated RBCs.
- Leukemoid rxn has mainly banded PMNs while CML has the whole spectrum.
- Leukmoid has more Leukocyte alkaline
Drug directed against abnormal tyrosine kinase in CML.
Polycythemia Vera is ____
3 increased cell types
Faster or slower blood flow?
- Increased RBC (>Hct 60%); slower blood flow
- Erythroid, Granulocytic, and megakaryocytic cells are all increased
Essential Thrombocytopenia (ET) is a hematopoietic stem cell disorder that primarily affects
Megakaryocytic cells (Platelets are increased, Giant platelets in the blood)
Plateles more than 450k
Hypercellualr marrow with large dysplastic and clustering megakaryocytes