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Where do some infammatory and infectious disease affect?
- - URT
- - Lung parenchma (connective and supportive tissue) pneumonia, TB
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What are some suppurative (puss) lung diseases?
- - Bronchiectasis
- - Lung abscess
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What are the parts of the upper and lower respiratory
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What is coryza?
- common cold
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WHat is coryzal?
- like those of the common cold
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Where does the common cold affect?
- the upper respiratory tract
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How is the common cold transmitted?
- droplet transmission
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What happens with the common cold?
- - infection and inflammation of the nasopharyngeal mucosa
- - extension of the infection beyonf the NP- pneumonia, bronchitis, otis media
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What is influenza?
- highly infectious actue viral illness caused by the influenza virus
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What are the characteristics of influenza?
- - pyrexia- fever
- - headache
- - myalgia- aches
- - malasie- feeling sick
- - fatigue and lethargy
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What is the aetilogy of influenza?
- - highly infectious
- - droplet spread
- - still a major cause of morbidity and mortality
- - high risk- age, comorbidities, immune compromised, resp disease
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What is the management of influenza?
- - supportive
- - preventative
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What are other URT infections that occur. Note we dont deal with this
- - epiglottitis- inflammation of the supraglottic region
- - laryngotracheobronchitis- croup, inflam of the subglottic region
- - pertussis- whooping cough, viral infection, characteristic cough
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How do you manage other URT
- - protect airway
- - humidification
- - antibiotics
- - inhaled adrenaline
- - corticosteroids
- - minimal handling
- - respiratory support as needed
- Physio- CI in acute phase but later only if there is specific lung pathology
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What are some conditions of the lwer respiratory tract?
- - bronchiolitis
- - pneumonia
- - PCP- classic pneuonia of aids
- -legionella
- - lung abscess
- - bronchiectasis
- - TB
- -
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What is bronchiolitis?
- inflammation of the bronchioles
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what is the aetiology of bronchiolitis?
- - most common LFT disease in childhood
- - usually caused by RSV (respsinovirus)
- - aerosol or direct transmission
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What is the process of bronchiolitis?
- - inflamm of bronchioles by viral pathogen
- - necrosis of the epithelium- sloughs into airway
- - airway oedma
- - increased mucous production
- - obstruction to small airways- air trapping or collapse, pneumonia/ consolidation
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What are the clinical signs and symptoms?
- - fever
- - resp distress
- - cough and secretions
- - ausc signs
- 0 CXR may show consolidation
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What is the management of bronchiolitis?
- medical
- - humidification with or without O2
- - ventilatory support needed
- - ABs i f secondary infection
- - medications- antiviral
- Physio
- - not indicated in acute stage
- - later in the disease course only if specific lung pathology and excessive secretions- only when u should handle them
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What is pneumonia?
- - INFLAMMATORY PROCESS AFFECTING THE LUNG PARENCHYMA- GAS EXCHANGE portion of the lung
- - significant world wide cause of morbidity and mortality
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What is pneumonia also known as?
- - Nosocomial/ Hospital acquired (HAP)
- - Community acquired (CAP)
- - Health associated (HCAP)
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What are the different causes of pneumonia?
- - typical vs atypical
- - bacteria- streptococuss, staphylococcus, klebsiella, pseudomonas, haemophillus, legionella
- - viruses: influenz, RSV
- - mycoplasma pneumoniae: small organisms which escapes isolation by standard tests
- - chicken pox
- - rubella- measles
- - fungal- aspergillus (in soil), histoplasmosa, candida
- - aspiration- alcoholics, people with poor conciousness, foreign substances into resp tract, URT secretions, gastric secretions, often anaerobic microbes- abcess, arapneumonic effusions
- - repeated pneumonia- suggestes aspiration, obstruction of bronchus eg Ca, perm lung damage
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who are at high risk of pneumonia?
- -poor resp defences
- - extremes of age- children and elderly
- - respdisease acute or chronic eg COPD
- - other chronic disease eg DM
- - debilitated
- - malnourished
- - immunocompromised
- - hospital pts
- - ETOH/ Drugs
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What is the pathology of pneumonia?
- -infetion of lung parenchyma with pathogen
- -filling of alvoli- fluid, secretions, RBCs, white blood cells, macrophages
- - consolidation of lung- poor alveolar ventilation, VQ mismatch, hypoxaemia
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what are the two stages of pneumonia?
- - cosolidation stage- initial stage
- - resoution stage- break up of alveolar consolidation, may become productive
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pneumonia may effect pleura
- parapneumonic effects
- empyema
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What are the clinical signs and symptoms of pneumonia?
- - fever increase WCC
- - flu like symptoms- my/arthralgia, malaise, headache, N&V
- - pleural pain
- - cough- dry/ productive
- - increased RR and HR
- - ausc- BBS, crackles, reduced BS
- - CXR- vary, consol
- - ABGS- hypoxameia
- - sputum culture
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what are the complications with pneumonia?
- - perm damage to lung
- - bronchiectasis, lung abscess
- - pleural effusion- parapneumonic (in pleural space), empyema (puss)
- - sepsis and multiorgan failure
- - resp failure
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what is the management of pneumonia?
- - hospital admission
- - antibiotics
- - fluid management
- - analgesics
- - oxygen therapy to mantain PaO2
- - other supportive therapy as needed
- PHYSIO
- - percs and vibes postural drainage in the resolution phase
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What is PCP?
- - classic pneumonia of AIDS
- - pneumocystis pneumonia
- - it is a fungus causiing infection in immunocompromised pts
- - diagnosed by analysis of sputum
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How do u manage PCP?
- - supportive
- - pharmacological
- - usually non productive therefore often no need for physio
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Lung abscesses?
- a localised collection of pus withing a caviated necrotic lesion in the lung parenchyma
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what causes a lung abscess?
- Anaerobic bacteria invading lung
- - bacteriodes
- - normally inhabit GIT and mouth
- - colonize gums (poor hygeine)
- - enter the lungs via aspiration
- Associated with
- - ETOH
- - Loss of consciousness
- - dysphagia
- Causes:
- - other bacteria invading lung eg E. coli
- - bronchial obstuction with secondary infection
- - vascular obstruction eg PE
- - interstitial lung disease
- - blood born infection- sepsis
- - infective bullae (bubble thing)
- - transdiaphragmatic spread
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What is the pathology of a lung abscess?
- - as for pneumonia in the early stages- lung consolidation
- - progression to tissue necrosis and destruction of tissue- cavity formation
- - cavity filled with air and infected material
- - may be encapsulated in a yogenic membrane- fibrosis, inflammatory, granu;lation tissue
- - may rupture into a bronchus into the pleural cavity- bronchopleural fistula, empyema, drainage of fluid
- - compression of surrounding lung
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What are the signs and symptoms of lung abcess?
- - as for pneumonia
- - systemic signs
- - cough with purulent secretions
- - hasmoptysis
- - loss of weight
- - CXR/ CT findings- cavity, airfluid levels
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how do u manage lung abcess?
- medical
- - antibiotics
- - biopsy
- - supportive therapy
- - surgery
- Physio
- - postural drainage may be required if abcess is draining
- - affected area uppermost- gravity assisted
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What is bronchiectasis?
anatomically defined by chronic, irreversible dilation and distortion of the bronchi caaused by inflam destruction of the mm and elastic components of bronchial walls
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what is the epidemiology of bronchiectasis?
- incidence in developed countrie unknow- low
- - less overcrowding
- - better hygiene
- - high immunisation rates
- - better nutrition
- - access health care
- - prevalance in indigenous aust and pacific isalnders- highest in the world
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what is the aetiology of bronchiectasis?
- - idiopathic
- - acquired
- -chronic lung infection
- - pneumonia, CF
- - chronic aspiration
- - subsequent to childhood infections
- - immunodeficiency
- - may also occur distal to obstructed bronchus- foreign body, lymph node
- - congenital- kartagener's syndrome, primary ciliary diskinesia, hypogammaglobulinemia
- - associated with other diseases- often autoimmune- RA, chron's disease
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What is the pathology of bronchiectasis?
- - initialinsult and then ongoing inflam response
- - damage and destruction to airway- cartilage, smooth mm, elastin, blood vessels
- - reduced effectiveness of MCC- pooling of secretions, further infection and lung damage
- - small airways closure- may lead to gas trapping or alveolar collapse
- - scarring of fibrosis of airways
- - both obstructive and restrictive
- - local or diffuse
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what are the three anatomical variations of bronchiectaisis?
- - cylindrical
- - varicose
- - cystic/ saccular
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what is the cylindrical bronchiectasis?
- dialated bronchi which fail to taper
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what is varicose bronchiectasis?
- - irregular dilation
- - like varicose veins
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what is cystic bronchiectasis?
- bronchi dialated and ending in cysts
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what are the signs and symptoms of bronchiectasis?
- - cough with secretions
- - ausc- crackles and wheezes
- - ABGs, PFTS
- - CXR- tramlines, ring like shadows, outlines of thickened and dilated bronchi
- - CT- HRCT (high resp CT) gold standard diagnostic tool, dilated airways, no tapering
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what are the signs and symptoms of acute exacerbation of bronchiectasis?
- - increased cough with more secretions, change colour
- - haemoptysis
- - signs of resp compromise
- - ausc crackles, wheezes
- - pleutric pain
- - cxr- increased consolidation, secretions in bronchi, cysts etc
- do tend to cough up blood due to erroded blood vessels
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how do u mantain brochectasis?
- - secretion clearance
- - antibiotics
- - resp medications as appropriate
- - vaccinations
- - pulm rehab
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manage bronchiectasis
- Acute- ABs- may be IV, other supportive treatment
- Surgery- remove affected lobes
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How do physios manage bronchiectasis?
- - effective clearance- PD, P&V, ACBT, PEP< FLutter
- - self management and edu
- - exercise training and rehab
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what is TB?
- - infectious disease caused by myocobacterium TB
- - particularly affects the lungs
- - one of the oldest disease known to affect human
- - old term consumption
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WHO TB?
- - > 5 mill new cases reported to WHO each yr
- - 95% from developing countries
- - under reported, 9 million estimated new cases per yr
- - 15-20million
- - 2 million die each
- - incidence stable or slightlydecling
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Tb in the developed world
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Tb bacteria
- - aerobic
- - thrive off areas of high O2
- - doesnt cahnge colour with acid stains
- - dropplet transmission
- - can remain in air for several hours
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what are the clinical signs and symptoms
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