REVIEW 3

Charged amino acid to nonpolar amino acid -> hydrophobic pocket of beta to fit into alpha -> sickling.

decrease number of ovulations because means less repair that has to be done

• 14:18 Bcl2 overexpression
• waxing and waning lymphadenopathy

Direct Xa inhibitor -> increased PT and PTT

Endothelium proliferation, migration and differentiation

(RR-1) / RR

Ecchymosis, petechiae, and mucosal bleeding without signs of TTP/HUS, pancytopenia, marrow failure or splenomegaly

9:22 -> BCR-ABL -> overactive tyrosine kinase

ATP dependent efflxu pump in cancer for chemotherapeutics

large glycoproteins that mediate between cell adhesion and migration

AL amyloid -> renal failure

pancytopenia and dry Bone marrow aspiration

185 KD transmembrane glycoprotein -> tyrosine kinase

Tumor suppressor that is involved in gene repair and regulation of the cell cycle

Folic acid deficiency

From the liver and regulates iron content on the intestinal epithelium

• Microangiopathic hemolytic anemia
• Acute renal failure
• Thrombocytopenia

Caused by E. Coli and shigella

X-linked

• Eczema
• recurrent capsular infections
• thrombocytopenia

binds 50 sribosome and inhbits peptidyltransferase

Causes Aplastic anemia upon withdrawal

can increase mediastinum mass ->

• SVC syndrome
• dysphagia
• dyspnea
• stridor

• membrane problem (hereditary spherocytosis)
• Red cell dehydration

is a protooncogene

• no increase in PTT when protein C added
• -> DVT and PE

185 kD transmembrane glycoprotein -> tyrosine kinase -> epithelial growth and proliferation

Have rRNA so they stain blue on Wright Giemsa stain

targets gp41 -> fusion inhibitor of the membranes

• Mesenchymal origin
• Blue-red skin plaques on the extremities and mucus membranes
• HHV 8 and associated with HIV

• Located mostly in cerebellum
• Lesions are solid and cystic

• pancytopenia
• dry bone marrow biospy

• This is acute intermittent porphyria
• Defect in Porphobilinogen deaminase
• Treatment: glucose and heme (inhibit ALA synthase)

Unregulated iron uptake in the intestine -> liver cirrhosis and/or hepatocellular carcinoma

• Benign epidermal tumor that is tan brown flat and greasy
• Looks like stick on

decrease in FVC -> panacincar in the lower lobes

•  Ataxia/ dysarthria
• increased transaminases

Physiologic loss of iron through menstruation -> not shown until after menopasue

• Leukotrienes ->
• vasoconstriciton, bronchospasm, and increased vascular permeability

Scattered noncaseating granulomas

Salmon colored lesions on elbows, knees, gluteal cleft, penis, scalp

Hyperkeratosis, acanthosis, rete ridge elongation, mitotic activity above basal layer, decrease in stratum granulosum

• increase aminotransferase level
• increase PT, leukocytosis
• eosinophilia

neoplastic cells that block dermal lymphatics

Vitamin A responsible for differentiation of specialized epithelia -> pancreas squamos epithelia metaplasia in cystic fibrosis

Dystrophic calcification = cell injury and necrosis

• estrogen increase cholesterol secretion
• progesterone -> gallbladder hypomobility

• I- B/L hilar lymphadenopathy
• II- B/L hilar lympadenopathy + pulmonary infiltrates
• III- pulmonary infiltrates
• IV- fibrosis

intranuclear inclusions in keratinocytes and multinucleated giant cells

benign liver tumor