Clinical uses of antipsychotics, classic, 1st gen?
help with schitzophrenia (dopamine)
D2 receptor affinity
Side effects of low potency antipsychotics, classic, 1st gen?
Mydriasis and cycloplegia
constipation and urinary retention
decrease in sweating and hyperthermia
Side effects of high potency antipsychotics, classic, 1st gen?
Malignant neuroleptic syndrome (MNS)
Orthostatic hypotension exacerbated by antihypertensives.
extrapyramidal effects related: muscle rigidity and high fever, dystonic reactions, akathisia, pseudoparkinsonism, tardive dyskinesia (facial), disuse supersensitivity/up-regulation, may be irreversible.
clinical uses of Antipsychotics, newer agents, 2nd generation?
5-HT2 or other receptor affinity
better at treating adverse affective symptoms
partial D2 agonist
decreases parkinsonism adverse effects
Side effects of Antipsychotics, newer agents, 2nd generation?
Sedation and weight gain (associated with
diabetes type II)
malignant neuroleptic syndrome
increased mortality in geriatric patients and dementia (equivalent risk for conventional drugs)