Musculoskeletal system drugs

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Author:
skerwien
ID:
181711
Filename:
Musculoskeletal system drugs
Updated:
2012-11-05 12:43:40
Tags:
pharmacology
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Description:
pharmacology
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  1. Endogenous drugs involved in bone homeostasis?
    • parathyroid hormone
    • vitamin D
    • calcitonin
    • glucocorticoids
    • estrogen
    • biophosphonates
    • floride
  2. Teriparatide?
    Parathyroid hormone (injection)
  3. secalcifediol?
    vitamin D
  4. clinical uses of vitamin D?
    • Helps store calcium.
    • Formed in liver and kidneys through light and diet as well. Stored in adipose tissue.
  5. clinical use of glococorticoids?
    Antagonize vit D, stimulate mobilization of calcium
  6. Calcitonin?
    • Peptide hormone secreted from thyroid parafolicular cells
    • nasal sprays or injection, calcitonin salmon
  7. soltamox?
    blocks estrogen for cancers
  8. raloxifene?
    estrogen that reduces fracture incidents
  9. alendronate?
    biophosphonate
  10. etidronate?
    biophosphonate
  11. risedronate?
    biophosphonate
  12. ibandronate?
    biophosphonate
  13. clinical use of biophosphonates?
    • Reduce formation and resorption of bone.
    • Post menopausal women
  14. Diazepam?
    benzodiazepine
  15. Drugs for muscle spasm?
    Benzodiazepines, opioids, polysynaptic inhibitors, NSAIDs, and botulinum toxin
  16. cyclobenzaprine?
    polysynaptic inhibitor
  17. carisoprodol?
    polysynaptic inhibitor
  18. metaxalone?
    polysynaptic inhibitor
  19. clinical uses of polysynaptic inhibitor?
    • Decrease in a motor neuron stimulation
    • general CNS depressant effect
  20. Side effects of polysynaptic inhibitors?
    • General CNS depressant effect (sedation and drowsiness, delayed psychomotor response)
    • amnesia
    • residual effect (hangover)
    • GI/CV/Respiratory depression
    • behavioral changes
    • tolerance
    • addiction/dependence
    • withdrawal and rebound anxiety

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