BioChem Gluconeogenesis

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Author:
bradley.knox
ID:
182512
Filename:
BioChem Gluconeogenesis
Updated:
2012-11-08 20:29:23
Tags:
BioChem gluconeogenesis
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Description:
gluconeogenesis
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  1. Where does gluconeogenesis primarily occur?
    • Liver
    • kidney
    • brain
  2. what is the net cost of GNG per pyruvate?
    6 ATP
  3. What are the three main substrates of gluconeogenesis?
    • Glycerol
    • Lactate
    • Alpha keto acids
  4. What is the enzyme that bypasses Hexokinase?
    Glucose-6-Phosphatase
  5. What is the enzyme that bypasses PFK?
    Fructose-1,6-bisphosphatase
  6. What two enzymes bypass pyruvate kinase?
    • Pyruvate carboxylase
    • PEP carboxykinase (PEP-CK)
  7. What enzyme is used to convert pyruvate to oxaloacetate and what is lost?
    • Pyruvate carboxylase
    • lose 1 ATP per Pyruvate
  8. What enzyme is used to convert oxaloacetate to PEP? What is lost?
    • PEP-carboxy kinase
    • lose 1 GTP per pyruvate
  9. What enzyme is used to convert fructose-1,6-bisphosphate to fructose-6-phosphate?
    Fructose-1,6-bisphosphatase
  10. What enzyme is used to convert glucose-6-phosphate to glucose?
    glucose-6-phosphatase
  11. How many ATP equivelent are lost during gluconeogenesis per glucose molecule gained?
    12 ATP equi

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