PODA III

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Author:
alvo2234
ID:
182654
Filename:
PODA III
Updated:
2012-11-11 13:01:50
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AOC
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Description:
AOC exam 3
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  1. Indications of Androgens
    • Severe anemia
    • Mangage impotence
    • Delayed pubery
    • Hereditary angioadema
    • Fibrocystic angioedema
    • Endometriosis
    • Decreased gonadism
    • Prevention/management of male menopause
    • Increased physical activity
    • Increased appetite (AIDS Cancer)
    • Increased height stature of pts
    • Breast cancer
    • Breast engorgement/pain
  2. Anticancer regimen used for gastric cancer
    • FAM (5-FU/Adriamycin/Mitomycin)
    • FAME (5-FU/Adriamycin/Methyl CCNU)
    • FCE (5-FU/Cisplatin/ Etoposide)
    • ELF (Etoposide/Leucovorin/5-FU)
    • FAMTX (5-FU/Adriamycin/Methotrexate)
    • FUP (5-FU/Platinol)
  3. Anticancer combos for breast cancer
    • CAF (cyclophosphamide/Adriamycin/5-FU)
    • FAC (5-FU/Adriamycin/cyclophosphamide)
    • FEC (5-FU/Epirubicin/Cyclophosphamide)
    • NFL  (Novantrone/5-FU/Leucovorin)
    • CMF (Cyclophosphamide/Methotrexate/5-FU)
    • CFM (Cyclophosphomide/5-FU/Methotrexate)
    • CMFVP (Coopers regimen)
    • TD, TV, TP, TCD
  4. Cisplatin AE
    • Nephrotoxicity-TLT
    • -Ototoxicity
    • -Neurotoxicity- peripheral neur., seizures
    • -Electrolyte imbalance (low Mg, K, Na, Ca, PO4)
    • -Ocular- papilledema, optic neuritis, chromatopsia, blindness, blurry vission
    • -Hypersensitivity
    • -SIADH
    • -1 and 2 similar AE of aminoglycosides
  5. 5-FU AE
    • Acute Coronary Syndrome- angina/MI
    • Acute Cerebellar Syndrome- HA, Malaise, Depression, Drowsiness
    • Eyes- Diplopia, Photophobia, Dryness, Lacrimation, blurry vision
    • GI- Inflm. and bleeding (esophogitis, stomatitis, intra abd. bleeding
    • BMD
    • Skin- rash, dermatitis
    • Photosensitivity
    • Increased sensitivity
    • Alopecia
    • Fever
  6. Gefitinib MOA
    selective, reversible EGFR inhibitor on lung cancer cells
  7. Erlotinib MOA
    inhibits the tyrosine kinase domain of EGFR on cell surface of lung cancer
  8. Teniposide MOA
    inhibits topoisomerase II, prevents resealing of DNA
  9. Vincristine
    inhibits microtubule formation, inhibits DNA/RNA synthesis
  10. Sunitinib
    multikinase inhibitor (including VEGF and PDGF)
  11. Pharmacological Actions of Progestins
    • convert endometrium to secretive and receptive
    • stimulate insulin release
    • inhibit gonadotropins from pituitary
    • increase appetite (AIDS, cancer)
    • Prevent Uterine Contraction
  12. Progestin Indications
    • infertility
    • Cachexia, anorexia
    • Decreased labor
    • management of amenorrhea
    • oral contraceptives
    • osteoporosis
    • hot flashes
    • palliative treatments of breast cancer
    • prevent PMS
    • abnormal uterine bleeding
  13. ADME of Mifepristone
    • ROA- PO
    • t1/2- 20-40 hrs
    • PPB- binds to alpha-glycoprotein
    • Excretion- fecal excretion
    • Metabolism: 3A4 (demethylation, OH- are metabolites)
  14. ADME of Estrogens
    • ROA- PO, IV, IM, topical, vaginal
    • Distribution- estradiol, estrone- SSBG, and EES to albumin
    • t1/2- EES 13-17 hrs, the rest just minutes
    • Metabolism- Estradiol---Estrone---estriol---urine
    •                     EES can be hydroxylated to 2 or 3 ME
    •                     3 ME is available as mestranol
    •                     metab. by 3A4, 1A2, 2B1 to catechols
    • Excretion- Renal
  15. anti VEGF used to treat colorectal cancer
    • Bevacizumab (Avastin)
    • Semaxinib
  16. Trastuzumab (Herceptin) based therapy
    • TD (doxitaxel)
    • TV (Vinorelbine)
    • TCP (Carboplatin/Paclitaxel)
    • TP (Paclitaxel)
  17. Drugs with Cardiotoxic TLT
    • Doxorubicin (Adriamycin)
    • Daunorubicin (Cerubidine)
    • Idarubicin (Idamycin)
    • Epirubicin (Ellence)
  18. Drugs with BMD TLT
    • 5-FU
    • Vinorelbine (Navelbine)
    • MTX (Rhematrex, Trexall)
  19. Drugs with Neurotoxic TLT
    • Vindesin
    • Vincristine (Oncovin, Vincasar)
  20. Drugs with nephrotoxic TLT
    • Cisplatin
    • Platinol
  21. Drugs with Hemorrhagic cystitis TLT
    • Cytoxan (cyclophosphamide)
    • Ifosphamide (Ifex)
  22. Drugs with Hemorrhagic enteritis TLT
    MTX (Rheumatrex, Trexall)
  23. Drugs with pulmonary fibrosis TLT
    • Bleomycin (Blenoxane)
    • Mitoxantrone 
    • Mitomycin (Mutamycin)
  24. Contraindications of Mifeprex
    • Asthma
    • Anemia
    • adrenal insufficiency
    • prolonged glucocorticoid use
  25. Streptozocin (Streptozotocin) use
    used in pancreatic insulinoma, malignant carcinoid
  26. Sunitinib (Sutent) use
    can be used to treat chronic neutrophilic leukemia
  27. Iressa (Gefitinib) use
    Can be used to treat ovarian cancer, NSCLC, prostate, and colorectal cancer
  28. Cladribine (leustatin) use
    used in paricell leukemia (oat cell leukemia)
  29. Pentostatin (2 prime deoxycoformycin) use
    used in oat cell leukemia

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