|
Home > Preview
The flashcards below were created by user
alvo2234
on FreezingBlue Flashcards.
-
Indications of Androgens
- Severe anemia
- Mangage impotence
- Delayed pubery
- Hereditary angioadema
- Fibrocystic angioedema
- Endometriosis
- Decreased gonadism
- Prevention/management of male menopause
- Increased physical activity
- Increased appetite (AIDS Cancer)
- Increased height stature of pts
- Breast cancer
- Breast engorgement/pain
-
Anticancer regimen used for gastric cancer
- FAM (5-FU/Adriamycin/Mitomycin)
- FAME (5-FU/Adriamycin/Methyl CCNU)
- FCE (5-FU/Cisplatin/ Etoposide)
- ELF (Etoposide/Leucovorin/5-FU)
- FAMTX (5-FU/Adriamycin/Methotrexate)
- FUP (5-FU/Platinol)
-
Anticancer combos for breast cancer
- CAF (cyclophosphamide/Adriamycin/5-FU)
- FAC (5-FU/Adriamycin/cyclophosphamide)
- FEC (5-FU/Epirubicin/Cyclophosphamide)
- NFL (Novantrone/5-FU/Leucovorin)
- CMF (Cyclophosphamide/Methotrexate/5-FU)
- CFM (Cyclophosphomide/5-FU/Methotrexate)
- CMFVP (Coopers regimen)
- TD, TV, TP, TCD
-
Cisplatin AE
- Nephrotoxicity-TLT
- -Ototoxicity
- -Neurotoxicity- peripheral neur., seizures
- -Electrolyte imbalance (low Mg, K, Na, Ca, PO4)
- -Ocular- papilledema, optic neuritis, chromatopsia, blindness, blurry vission
- -Hypersensitivity
- -SIADH
- -1 and 2 similar AE of aminoglycosides
-
5-FU AE
- Acute Coronary Syndrome- angina/MI
- Acute Cerebellar Syndrome- HA, Malaise, Depression, Drowsiness
- Eyes- Diplopia, Photophobia, Dryness, Lacrimation, blurry vision
- GI- Inflm. and bleeding (esophogitis, stomatitis, intra abd. bleeding
- BMD
- Skin- rash, dermatitis
- Photosensitivity
- Increased sensitivity
- Alopecia
- Fever
-
Gefitinib MOA
selective, reversible EGFR inhibitor on lung cancer cells
-
Erlotinib MOA
inhibits the tyrosine kinase domain of EGFR on cell surface of lung cancer
-
Teniposide MOA
inhibits topoisomerase II, prevents resealing of DNA
-
Vincristine
inhibits microtubule formation, inhibits DNA/RNA synthesis
-
Sunitinib
multikinase inhibitor (including VEGF and PDGF)
-
Pharmacological Actions of Progestins
- convert endometrium to secretive and receptive
- stimulate insulin release
- inhibit gonadotropins from pituitary
- increase appetite (AIDS, cancer)
- Prevent Uterine Contraction
-
Progestin Indications
- infertility
- Cachexia, anorexia
- Decreased labor
- management of amenorrhea
- oral contraceptives
- osteoporosis
- hot flashes
- palliative treatments of breast cancer
- prevent PMS
- abnormal uterine bleeding
-
ADME of Mifepristone
- ROA- PO
- t1/2- 20-40 hrs
- PPB- binds to alpha-glycoprotein
- Excretion- fecal excretion
- Metabolism: 3A4 (demethylation, OH- are metabolites)
-
ADME of Estrogens
- ROA- PO, IV, IM, topical, vaginal
- Distribution- estradiol, estrone- SSBG, and EES to albumin
- t1/2- EES 13-17 hrs, the rest just minutes
- Metabolism- Estradiol---Estrone---estriol---urine
- EES can be hydroxylated to 2 or 3 ME
- 3 ME is available as mestranol
- metab. by 3A4, 1A2, 2B1 to catechols
- Excretion- Renal
-
anti VEGF used to treat colorectal cancer
- Bevacizumab (Avastin)
- Semaxinib
-
Trastuzumab (Herceptin) based therapy
- TD (doxitaxel)
- TV (Vinorelbine)
- TCP (Carboplatin/Paclitaxel)
- TP (Paclitaxel)
-
Drugs with Cardiotoxic TLT
- Doxorubicin (Adriamycin)
- Daunorubicin (Cerubidine)
- Idarubicin (Idamycin)
- Epirubicin (Ellence)
-
Drugs with BMD TLT
- 5-FU
- Vinorelbine (Navelbine)
- MTX (Rhematrex, Trexall)
-
Drugs with Neurotoxic TLT
- Vindesin
- Vincristine (Oncovin, Vincasar)
-
Drugs with nephrotoxic TLT
-
Drugs with Hemorrhagic cystitis TLT
- Cytoxan (cyclophosphamide)
- Ifosphamide (Ifex)
-
Drugs with Hemorrhagic enteritis TLT
MTX (Rheumatrex, Trexall)
-
Drugs with pulmonary fibrosis TLT
- Bleomycin (Blenoxane)
- Mitoxantrone
- Mitomycin (Mutamycin)
-
Contraindications of Mifeprex
- Asthma
- Anemia
- adrenal insufficiency
- prolonged glucocorticoid use
-
Streptozocin (Streptozotocin) use
used in pancreatic insulinoma, malignant carcinoid
-
Sunitinib (Sutent) use
can be used to treat chronic neutrophilic leukemia
-
Iressa (Gefitinib) use
Can be used to treat ovarian cancer, NSCLC, prostate, and colorectal cancer
-
Cladribine (leustatin) use
used in paricell leukemia (oat cell leukemia)
-
Pentostatin (2 prime deoxycoformycin) use
used in oat cell leukemia
|
|
Get the free mobile app
Take the Quiz
Learn more
Learn more