NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride

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Anonymous
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18273
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NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride
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2010-05-08 00:53:54
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NCTI Pharmacology Drug List Hydromorphone Hydrochloride
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NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride
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  1. Hyrdromorphone hydrochloride
    Mechanism of Action
    • 1.
    • Binds with opiate receptors in brain, altering
    • perception and emotional response to pain.

    • 2.
    • suppresses the cough reflex by direct action on the
    • cough center in the medulla oblongata.
  2. hydromorphone hydrochloride
    class
    narcotic analgesic
  3. hydromorphone hydrochloride
    trade name
    Dilaudid
  4. hydromorphone hydrochloride
    Indications
    • 1. moderate to severe pain
    • 2. persistent cough
  5. hydromorphone hydrochloride
    contraindications
    • 1.
    • increased intracranial pressure

    • 2.
    • respiratory depression / inadequacy – such as in
    • COPD, status asthmaticus

    • 3.
    • circulatory compromise
  6. hydromorphone hydrochloride
    side effects
    • CNS: sedation, dizziness, lightheadedness, somnolence, blurred
    • vision, nystagmus

    Cardiovascular: hypotension, bradycardia

    Respiratory: respiratory depression or arrest, bronchospasm

    GI: nausea / vomiting, constipation
  7. hydromorphone hydrochloride
    precautions
    • Use with caution in head
    • injuries; the elderly, debilitated or immuno-compromised patients; COPD or
    • other respiratory problems and those with kidney or liver dysfunction.
  8. hydromorphone hydrochloride
    interactions
    • Other CNS depressants, general
    • anesthetics, MAO inhibitors, other opioid analgesics, sedatives, tranquilizers,
    • and tricyclic antidepressants may potentiate the effects of Dilaudid.
  9. hydromorphone hydrochloride
    routes of administration
    IV, IO, IM, SQ, PR and PO
  10. hydromorphone hydrochloride
    onset and duration
    • IV and IM administration most
    • common in the hospital setting – IV: onset in 10-15 minutes, peaks in 15-30
    • minutes and lasts 2-3 hours. IM: onset in 15 minutes, peaks in 30-60 minutes,
    • and lasts 4-5 hours.
  11. hydromorphone hydrochloride
    For Pain Control:

    • Adults: 1-4 mg IM, SQ or SLOW IV push (over at least 2-5
    • minutes) every 4-6 hours



    • Pediatrics: Rarely given for pain control – primarily for
    • cough suppressant effects.



    For Cough:

    Adults and children > 12 years: 1 mg cough syrup PO every 3-4 hours



    • Children ages 6-12 years: 0.5 mg of cough syrup every 3-4
    • hours
  12. hydromorphone hydrochloride
    notes
    often used in clinical internship setting

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