NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride

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RunNickMarini
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18276
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NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride
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2010-05-08 01:36:16
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NCTI Pharmacology Drug List Hydromorphone Hydrochloride
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NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride
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  1. Hydromorphone Hydrochloride
    trade name
    Dilaudid
  2. Hydromorphone Hydrochloride
    class
    Narcotic Analgesic
  3. Hydromorphone Hydrochloride
    mechanism of action
    • 1. Binds with opiate receptors in brain, altering perception and emotional response to pain.
    • 2. suppresses the cough reflex by direct action on the cough center in the medulla oblongata.
  4. Hydromorphone Hydrochloride
    indications
    • 1. moderate to severe pain
    • 2. persistent cough
  5. Hydromorphone Hydrochloride
    contraindications
    • 1. increased intracranial pressure
    • 2. respiratory depression / inadequacy – such as in COPD, status asthmaticus
    • 3. circulatory compromise
  6. Hydromorphone Hydrochloride
    side effects
    • CNS: sedation, dizziness, lightheadedness, somnolence, blurred vision, nystagmus
    • Cardiovascular: hypotension, bradycardia
    • Respiratory: respiratory depression or arrest, bronchospasm
    • GI: nausea / vomiting, constipation
  7. Hydromorphone Hydrochloride
    precautions
    Use with caution in head injuries; the elderly, debilitated or immuno-compromised patients; COPD or other respiratory problems and those with kidney or liver dysfunction.
  8. Hydromorphone Hydrochloride
    interactions
    Other CNS depressants, general anesthetics, MAO inhibitors, other opioid analgesics, sedatives, tranquilizers, and tricyclic antidepressants may potentiate the effects of Dilaudid.
  9. Hydromorphone Hydrochloride
    routes
    IV, IO, IM, SQ, PR and PO
  10. Hydromorphone Hydrochloride
    onset and duration
    IV and IM administration most common in the hospital setting – IV: onset in 10-15 minutes, peaks in 15-30 minutes and lasts 2-3 hours. IM: onset in 15 minutes, peaks in 30-60 minutes, and lasts 4-5 hours.
  11. Hydromorphone Hydrochloride
    dosage
    • For Pain Control:
    • Adults: 1-4 mg IM, SQ or SLOW IV push (over at least 2-5 minutes) every 4-6 hours
    • Pediatrics: Rarely given for pain control – primarily for cough suppressant effects.

    • For Cough:
    • Adults and children > 12 years: 1 mg cough syrup PO every 3-4 hours
    • Children ages 6-12 years: 0.5 mg of cough syrup every 3-4 hours
  12. Hydromorphone Hydrochloride
    notes
    Often used in the clinical internship setting.

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