What is one of the most common malignant neoplasms of the female reproductive tract? When does it occur most often in women? What is one of its strongest etiological associations? What may precede it?
- Endometrial carcinoma: a type of adenocarcinoma arising from the endometrial glands that often replicates their structure
- Occurs: most often in perimenopausal and menopausal women, but may be seen in younger women too
- Strongest etiological association: replacement estrogen therapy (obesity is also a risk factor)
- May be preceded by: pre-malignant phase of endometrial hyperplasia (this can regress or progress to carcinoma)