Opioids

Card Set Information

Author:
Spykenard
ID:
183023
Filename:
Opioids
Updated:
2012-11-11 21:10:54
Tags:
Pharmacology
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Description:
Pharmacology
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  1. What is the gold standard for treating chronic pain?
    Opioids alone or in combination with non-opioid analgesics
  2. What occurs in the PAG (peri-acqueductal gray)?
    Midbrain processing center; high concentration of opioid receptors, modulation of pain response in descending endogenous pain suppressant pathways.
  3. What are the three endogenous opioid agonists?
    • Enkephalin
    • Dynorphan
    • Endorphans
  4. What is psychotomimesis?
    Psychotic-like behavior (hallucinations, dysphoria)
  5. What are common effects of Mu receptors?

    (Hint: PEAR)
    • Physical dependence
    • Euphoria
    • Analgesia
    • Respiratory depression
  6. What are the common effects of Kappa receptors?

    (Hint: SAD/M/P)
    • Sedation
    • Analgesia
    • Diuresis
    • Miosis
    • Psychotomimesis
  7. What are the common effects of Delta agonists?

    (Hint: ARGH)
    • Analgesic
    • Releases Growth Hormone
  8. What is the main MOA for opioids?
    Opioids inhibit adenylyl cyclase, increase K+ influx, reduce Ca2+ influx, and therefore decrease neurotransmitter release

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