NCTI- Pharmacology- Drug List J- Fentanyl

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  1. Fentanyl
    trade name
  2. Fentanyl
    narcotic analgesic
  3. Fentanyl
    mechanism of action
    Provides analgesia and sedation by acting on the opiate receptors in the brain, blocking sensation of pain.
  4. Fentanyl
    • 1. sedation during rapid sequence intubation
    • 2. control severe pain
  5. Fentanyl
    • 1. patients who have received MAO inhibitors in the last 14 days
    • 2. myasthenia gravis
    • 3. safe use in pregnancy and in children < 2 years old not established
  6. Fentanyl
    side effects
    • CNS: sedation, euphoria, dizziness, diaphoresis, seizures with high doses, delirium
    • Cardiovascular: hypotension, bradycardia, circulatory depression, cardiac arrest
    • Respiratory: respiratory depression or arrest, bronchoconstriction, laryngospasm
    • GI: nausea/vomiting, constipation
  7. Fentanyl
    Use with caution in head injuries, suspected or known increased intracranial pressure; the elderly, debilitated or immuno-compromised patients; COPD or other respiratory problems and those with kidney or liver dysfunction.
  8. Fentanyl
    Alcohol and other CNS depressants potentiate effects of fentanyl; MAO inhibitors may precipitate hypertensive crisis.
  9. Fentanyl
    IV, IO, IM (also found in home medication form in the transdermal patch)
  10. Fentanyl
    onset and duration
    Onset is immediate; peak effect in 3-5 min IV, 5-15 IM; duration is 30-60 minutes (or hours with transdermal patch).
  11. Fentanyl
    • Adult: 25-100 mcg SLOW IV push (over 2-3 minutes)
    • Pediatric (child > 2 years): 2.0 mcg/kg SLOW IV push or IM
  12. Fentanyl
    Fentanyl provides much faster acting, more prolonged pain relief. Duration of respiratory depressant effects may be significantly longer than analgesic effects – always have oxygen immediately available and be prepared with intubation equipment and a narcotic antagonist (i.e. naloxone).
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NCTI- Pharmacology- Drug List J- Fentanyl
NCTI- Pharmacology- Drug List J- Fentanyl
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