MED-Amiodarone

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Author:
amerelman
ID:
18335
Filename:
MED-Amiodarone
Updated:
2010-05-08 14:56:21
Tags:
MED Amiodarone
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Description:
MED-Amiodarone
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  1. Functional Class
    Class III Antidysrhythmic (potassium channel blocker)
  2. Mechanism of Action
    • -Acts directly on all cardiac tissues
    • -Prolongs duration of the action potential and refractory period by blocking potassium channels
    • -Also blocks sodium channels
    • -IV form relaxes vascular smooth muscle, decreases peripheral vascular resistance and increases coronary blood flow
    • -Blocks the effects of sympathetic stimulation
  3. Indications
    • -Life-threatening ventricular and supraventricular dysrhythmias
    • (VF, VT, A-Fib, A-Flutter, SVT, WPW)
  4. Contraindications
    • -Hypersensitivity
    • -Cardiogenic shock
    • -Severe sinus bradycardia
    • -AV block
  5. Precautions
    • -Severe liver disease
    • -Pregnancy
    • -Nursing mothers
  6. Side Effects
    • CHF
    • Angioedema
    • Hypotension
    • AV block
    • Hepatatoxicity
    • Cardiogenic shock
    • Fatigue
    • Bradycardia
    • Sinus arrest
    • Permanent blindness
    • N/V
    • Prolonged QT interval
  7. Interactions
    • Increases digoxin levels
    • Enhances effects of procainamide, lidocaine, quinidine, and oral anticoagulants
    • Calcium channel blockers, beta blockers, fentanyl, and cimetidine may potentiate sinus bradycardia
  8. Dose/Route
    • ADULT
    • Pulse:
    • 150 mg (in 50-100mL NS) IV over 10 mins. May repeat after 10 mins

    Pulseless: 300 mg IVP, repeat in 3-5 mins at 150 mg IVP

    Infusion: 1 mg/min over the next 6 hours

    • PEDI
    • 5 mg/kg IV/IO

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