Card Set Information
how do eosinophils destroy parasites?
stimulated by IgE bound to a parasitic cell
no blood or pus (not inflammatory)
not corrected by changes in diet (not osmotic)
inhibits H+ secretion
relaxes GI tract
stimulates HCO3- and Cl- secretion
released for PNS ganglia
Central sleep apnea
patient cannot initiate breaths
neurological, not mechanical problem
how to assess concentration vs. comprehension on a MMSE?
concentration: counting down by 7 from 100, spell world backwards
comprehension: follow a 4-step command
Bisphosphanates are structural analogs of what structure?
pyrophosphate, important component of hydroxyapetite
adverse effect of warfarin with a protein C deficiency
warfarin inhibits protein C further
leads to hyper-coagulation (protein C normally inhibits factors V and VIII)
thrombotic occlusion of microvasculature + skin/tissue necrosis
Aneurysm of the left PCA will cause CN III loss on what side?
left (I/L lesion)
Properties of an anesthetic with a high arterio-venous concentration gradient
Increases solubility in the tissues (high tissue uptake)
slow onset of action (more gas needed to saturate the blood)
* longer in the tissues, longer it takes to leave the tissues *
Primidone (anti-epileptic drug) can metabolize into?
phenobarbital and phenylethylmalonamide (PEMA), and increase the drug levels
Biopsy of what colon segment will be dx for Hirschprung's
submucosa and muscularis externa
dilated segments are proximal to the aganglionic segment part (distention occurs due to fecal retention)
Vitamin E function
protects fatty acids (eg. cell membranes) from oxidative stress
cells most susceptible to vitamin E def
: neurons and RBCs
C. difficile toxins A and B
: attracts neutrophils causing mucosal inflammation and loss of water into the gut
: cytotoxin; causes actin depolymerization, loss of cytoskeleton integrity, mucosal necrosis
Less common causes of acute pancreatitis (not alcohol or gallstones)
global sx with cerebral edema
intraparenchymal hemorrhage would give focal lesion deficits (e.g. sensory loss on 1 arm)
Branches off the ascending aorta
Brachiocephalic --> right common carotid and right subclavian
Left common carotid
autopsy findings of lacunar infarcts
small vessel lipohyalinosis and microartherosclerosis
Pyruvate kinase deficiency and splenomegaly
hemolytic anemia due to failure of glycolysis and cannot make ATP to main RBC structure
spleen has to increase its work to take out these deformed RBCs
Passive congestion of the spleen causing splenomegaly
portal HT, splenic vein thrombosis and congestive heart failure
splenic sinusoids dilate
age for first dose of tetanus vaccine
Corticosteroids cause what changes to the CBC
increase neutrophils (demargination from the vessel wall)
decrease eosinophils, basophils, lymphocytes, monocytes
Neurotransmitter affected in narcolepsy
low levels of hypocretin (orexin) - maintains wakefulness and suppresses REM-related causes
second-generation anti-histamines (less sedating and less adverse effects)
do not cross the BBB
B-blockers tx for hyperthyroidism
symptomatically to decrease HR and contractility
decreases peripheral conversion of T4 to T3 (cannot act on tissues)
Composition of vegetations of bacterial endocarditis
fibrin and platelet deposition
what is seen on stool microscopy of V.cholera?
no leukocytes or erythrocytes (does not invade the mucosa)
do not cause cell death
only epithelial cells and mucous
modify electrolyte imbalances by enterocytes
Hepatocyte injury with viral hepatitis
empty cytoplasmic spaces
hepatocyte death --> bridging necrosis connecting lobules, inflammation seen
Uric acid precipitates in what segment of the nephron?
low acidic environments
distal tubule and collecting duct
*uric acid is soluble at physiological pH*
Non-antidepressant drugs that can worse serotonin syndrome:
1) linezolid (weak MAO inhibitor, used to treat VRE)
3) tramadol (weak opiod agonist, inhibits 5HT and NE reuptake, causes seizures)
What chamber forms the diaphragmatic part of the heart, and supplied by what artery?
inferior wall of the LV
posterior descending a of the R coronary a.
left circumflex supplies the lateral and superior wall of the LV
Which Abx can increase penicillin's ability to penetrate bacteria?
Aminoglycosides (synergistic affect)
can penicillins treat Bacteriodes (anaerobic)?
: B-lactamase that breaks down penicillins
Pens only work if given with a B-lactam inhibitor.
Lipoprotein lipase deficiency will increase what levels
TG (cannot be transported by VLDL)
*seen with SLE*
cause of lacunar infarcts vs. charcoat-bouchard aneurysms
: hypertensive arteriolar sclerosis
lipohyalinosis and microartheromas
due to long-standing HT and are prone to rupture
hemorrhagic stroke is evident due to intraparenchymal hyperdensity
where are B1 receptors located?
* not located on vascular SM *
Liver has a dual blood supply to protect against infarcts, when can it not do this?
collateral blood supply is destroyed
zona occludens also known as?
AA sequence of collagen
where X and Y are proline and lysine
do platelet disorders (e.g. TTP and ITP) bleed? do they increase PT and PTT?
decrease PLT # and increase BT
what lab values lead to gallstone formation?
increased cholestrol and bilirubin
decreased bile salts
Treatment of MRSA with Daptomycin and Linezolid - MoA and adverse effects
: membrane depolarization, inhibition of DNA, RNA and protein synthesis
a/e = myopathy and increased CPK, inactivated by pulmonary surfactant
: binds to 50S and inhibits protein synthesis
a/e = thrombocytopenia, optic neuritis, can lead to serotonin syndrome
ulcerative-colitis associated colon cancer features
progresses from flat, non-polyp dysplasia
mucinous/signet cell appearance (higher histological grade)
early p53 and late APC mutations
multifocal in nature
patient presents with hematuria 2-3d after a respiratory infection vs. a few weeks later
: IgA nephropathy, C3 levels are normal
: PSGN, decreased C3 levels
Gottron's papules = red lesions over knuckles, elbows, knees
Herring bone pattern
Maligant fibrous histioctyoma
DNA repair defect for xeroderma pigmentosum vs. HNPCC
DNA excision repair
DNA mismatch repair
pulmonary edema due to LVF causes a decrease or increase in lung compliance
decrease due to fluid accumulation (= less air)
Prophylatic vaccine against rabies is what kind?
killed vaccine (part of live vaccine) = live viral strains grown and then inactivated
Patient undergoes invasive cervical cancer and now has right-sided flank pain radiating to groin and palpable kidney mass
damaged ureter = therefore, pressure backs up in the kidney which bladder cannot drain
proprionyl-coA is derived from what AA?
what does propionyl coA become?
: val, ile, met, thr and odd # FA
uses propionyl coA carboxylase to convert from propionyl coA to methymalonyl coA (which goes to succinyl coA)
GFAP stains + for what brain tumors?
What brain tumor stains GFAP - and synatophysyin -?
astrocytomas, GM, ependymoma, oligodendrogliomas
mengioma (dx by CT) from arachnoid cells
which requires more oxygen and produces more ATP?
: FA metabolism
sharing of antigen sites on host and organism
e.g. rheumatic fever
coughs on expiration and whoops on inspiration
inhibits Gi to increase cAMP
(croup = paramyxovirus (parainfluenza) - seal-like barking cough)
Reaction occurring from propionic coA to methylmalonyl coA and from methyl-coA to succinyl coA
carboxylation via propionyl coA carboxylase
isomerization via methyl-malonyl coA mutase (B12)
Most frequenct CNS tumor in AIDS patients
primary CNS lymphoma
often associated with EBV (B cell lymphoma)
how do patients with SIADH have a normal total body water
then, suppresses the RAAS system - decreased aldosterone will not absorb Na+ and hence, no water absorption either = salt wasting via the urine
total body water becomes equal
High potency and low potency anti-psychotics
: haloperidol, fluphenazine, pimozide
: clorpromazine, thioridazine
Direct thrombin inhibitors