- Classification- Therapeutic: allergy, cold, and cough remedies (antitussives), opioid analgesics
- Pharmacologic: Opioid agonists
Indications for use- Moderate to severe pain (alone and in combination with nonopioid analgesics); extended release product for opioid-tolerant patients requiring around the clock management of persistent pain.
Action- Binds ot opiate receptors in the CNS. Alters the preception of and response to painful stimuli while producing generalized CNS depression. Suppresses the cough reflex via a direct central action. Therapeutic: decrease in moderate to severe pain. Suppression of cough.
Contraindications/precautions- Hypersensitivity to hydroxychloroquine or chloroquine; previous visual damage from hydroxychloroquine or chloroquine. Use cautiously in concurrent use of hepatotoxic drugs. History of liver disease or alcoholism or renal impairment, severe neurological disorders, severe blood disorders, retinal or visual field changes, psoriasis, bone marrow depression; obesity. OB, lactation: avoid use unless treating malaria or treating amebic abcess. PEDI: long term use may increase sensitivity.
Life-threatening adverse reactions/most common side effects - CNS: SEIZURES, aggressiveness, anxiety, apathy, confusion, fatigue, headache. EENT: keratopathy, ototoxicity, retinopathy, tinnitus, visual disturbances CV: ECG changes, hypotension GI: abd cramps, anorexia, diarrhea, epigastric discomfort, nausea, vomiting, hepatic failure. DERM: bleaching of hair, alopecia, hyperpigmentation, photosensitivity, steven johnsons syndrome HEMAT: AGRANULOCYTOSIS, APLASTIC ANEMIA, leukopenia, thromocytopenia NEURO: neuromyopathy, peripheral neuritis.