A 68 year-old woman, 72 kg, is admitted to the hospital because of non-small cell lung cancer. Initially, she has normal renal function: serum creatine concentration of 118 micromoles/L. The patient will be treated with carboplatin as 1-hour infusion. The target AUC is 5mg/ml*min.
Determine an appropriate dose of carboplatin to achieve the desired AUC of 5mg/ml*min, by using the methods of Calvert.
Scr = serum creatinine concentrationAUC = area under plasma concentration-time curve
- GFR = [1.04 * (140 - age) * BW/ (Scr)] * 0.85 because female
- = [1.04 * (140 - 68) * 72/(118)] * 0.85
- = 38.84 ml/min
- Dose = target AUC * (GFR + 25)
- = 5 * (38.84 + 25)
- = 319.20 mg