Neoplasia Lab

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kris10leejmu
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183734
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Neoplasia Lab
Updated:
2012-11-14 22:45:32
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Lab Tech ll Practical
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Lab Tech ll
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  1. What is fibrosarcoma composed of?
    • spindle cells, multinucleated giant cells and histiocytic cells
    • lymphocytic inflammation may be present
  2. What do spindle cells from fibrosarcoma look like?
    very large with abundant, basophilic cytoplasm
  3. What is fibrosarcoma?
    malignant tumor of connective tissue
  4. What does fibrosarcoma grossly feel like?
    firm, cutaneous, well defined mass
  5. What does the nuclei of cells look like on a cytology of fibrosarcoma?
    large, oval, have finely stippled chromatin and may have several nucleoli
  6. What is the injection site tumor in cats?
    fibrosarcoma
  7. When do we often see basal cell tumors?
    common skin tumor in middle-aged dogs and cats
  8. What is the most common skin tumor in cats?
    basal cell tumor
  9. Where on the body do we often see basal cell tumors on the body?
    head, neck, and shoulder
  10. Is ulceration common with basal cell tumors?
    yes
  11. What does the cytology of basal cell tumor look like?
    • small clusters, cords or ribbons of small uniform epithelial cells
    • cells have a high N:C ratio with scant basophilic cytoplasm
    • there is minimal variation in N:C ratio, cell size, and nuclear size
    • these cells are often broken
  12. Are basal cell tumors usually benign or malignant?
    benign
  13. What does a cytology of transmissible venereal tumors look like?
    • cytoplasm: moderate amount of smoky to light blue with distinct boundaries
    • many clear, distinctly walled vacuoles within cytoplasm with extracellularly
    • nuclei: round, show moderate variation in size with 1 or 2 very prominent, large nucleoli
    • chromatin: coarse, cord like
  14. Where on the body do we see transmissible venereal tumors?
    genitalia and lips of bred dogs
  15. Is melanoma benign or malignant?
    can be either
  16. Is melanoma common in dogs and cats?
    • common in dogs
    • rare in cats
  17. Where on dogs do we usually find melanoma?
    • cutaneous - usually benign
    • lips, oral, digit - usually malignant
  18. What does melanoma look like on a cytology?
    • moderate cellularity with small to moderate blood
    • most cells individual
    • round, oval, stellate, spindle shaped cells
    • cytoplasm - moderate to abundant that contain granules (brown to green-black), granules may be absent
  19. What kind of tumor is melanoma?
    discrete cell tumor
  20. Other than melanoma being common in dogs, what other animal is it common in?
    grey horses
  21. What does a cytology of a mast cell tumor look like?
    • abundance of distinct cytoplasmic granules that may obscure the nucleus
    • granules are round to oval, numerous and stain blue to purple-red
  22. What do we need to differentiate mast cell tumors from?  How do we tell the difference?
    • mast cell tumors must be differentiated from inflammatory processed that contain mast cells
    • the presence of inflammatory cells (neutrophils and macrophages) is important observations in this case
  23. What is the most common skin tumor in dogs?
    mast cell tumor
  24. What is the second most common skin tumor in cats?
    mast cell tumor
  25. Where on the dogs body do we typically find malignant mast cell tumors?
    • perineum
    • groin
    • around muzzle
  26. What is the prognosis for mast cell tumors?
    poor
  27. Do mast cell tumors have high or low cellularity?
    high
  28. What types of cells do we see on a cytology of mast cell tumors?
    • mast cells (predominant cell)
    • eosinophils and fibroblasts (spindle "elongated" or stellate "star" shapes)
  29. Where do we find transitional cell carcinoma?
    • urine sediment
    • dry prep stained with diff quik
  30. What types of animals are transitional cell carcinoma common in?
    aged dogs and rarely in cats
  31. What does a cytology of transitional cell carcinoma look like?
    • large cells with abundant cytoplasm are often interspersed with groups of cells that have higher N:C ratios
    • nuclei are round to oval with coarse chromatin which is a common cytomorphological feature in the urethelial system
  32. Which tumor is common in young dogs?
    histiocytoma
  33. Are histiocytomas benign or malignant?
    usually benign
  34. Can histiocytomas get better on their own?
    yes
  35. What does a cytology of a histiocytoma look like?
    • slightly larger than neutrophils
    • moderate amount of pale blue cytoplasm that may stain lighter than the background if a significant amount of proteinaceous background is present
    • nuclei are round/oval/irregular with finely etched, lacy or finely stipples chromatin
    • may contain multiple, small, indistinct nucleoli
  36. What can histiocytoma be confused with?
    lymphoma
  37. What are dermal plasma cell tumors called?
    plasmacytoma
  38. Where do we often see plasmacytomas on the body?
    • facial regions
    • digits
    • mouth
  39. What does a cytology of plasmacytoma look like?
    • plasma cells or discrete cells
    • perinuclear clear zones may not be present despite characteristic eccentric nuclei
    • multinucleated cells are common
  40. What is the second type of plasma cell tumor and where is it found?
    • multiple myeloma
    • found in the bone marrow, liver and spleen
    • these tumors have an abundance of plasma cells
  41. What does a cytology of a mammary gland adenocarcinoma look like?
    • cells occur singly and in clusters
    • round with a round to oval, eccentrically placed nucleus
    • cytoplasm variablyl sized that occasionally contains vacuoles with secretory product
    • cell borders are indistinct
    • nuclear giant forms may be present
  42. What does a cytology of a sarcoma look like?
    • spindle shapped or stellate cells with tapering extensions of blue cytoplasm
    • cell borders are indistinct and nuclei are typically oval and placed near the center of the cell
    • chromatin can be moderatly condensed to finely reticular
    • nucleoli can be inapparent or very prominent and large
  43. fibrosarcoma

    • spindle cells and multinucleated giant cells
    • the spindle cells can be very large and have abundant, basophilic cytoplasm
    • nuclei are large, oval, have finely stippled chromatin and may have several nucleoli
  44. fibrosarcoma

    • spindle cells and multinucleated giant cells
    • spindle cells can be very large and have abundant, basophilic cytoplasm
    • nuclei are large, oval, have finely stippled chromatin and may have several nucleoli
  45. fibrosarcoma

    • spindle cells and multinucleated giant cells
    • spindle cells can be very large and have abundant, basophilic cytoplasm
    • nuclei are large, oval, have finely stippled chromatin and may have several nucleoli
  46. basal cell tumor

    • small clusters, cords, or ribbons of small uniform epithelial cells
    • cells have a high N:C ratio with basophilic cytoplasm
    • there is minimal variation in N:C ratio, cell size, and nuclear size
  47. basal cell tumor

    • small clusters, cords, or ribbons of small uniform epithelial cells
    • cells have a high N:C ratio with basophilic cytoplasm
    • there is minimal variation in N:C ratio, cell size, and nuclear size
  48. transmissible venereal tumors

    • discrete cell tumor
    • cytoplasm:  moderate amount of smoky to light blue with distinct boundaries
    • many clear, distinctly walled vacuoles within cytoplasm
    • nuclei:  round, show moderate variation in size with 1 or 2 very predominant, large nucleoli
    • chromatin:  coarse, cord like
  49. transmissible venereal tumors

    • discrete cell tumor
    • cytoplasm:  moderate amount of smoky to light blue with distinct boundaries
    • many clear, distinctly walled vacuoles within cytoplasm
    • nuclei:  round, show moderate variation in size with 1 or 2 very predominant, large nucleoli
    • chromatin:  coarse, cord like
  50. transmissible venereal tumors

    • discrete cell tumor
    • cytoplasm:  moderate amount of smoky to light blue with distinct boundaries
    • many clear, distinctly walled vacuoles within cytoplasm
    • nuclei:  round, show moderate variation in size with 1 or 2 very predominant, large nucleoli
    • chromatin:  coarse, cord like
  51. melanoma

    • moderate cellularity with small to moderate blood
    • most cells individual
    • round, oval, stellate, spindle shaped
    • cytoplasm:  moderate to abundant that contain granules (brown to green-black)
  52. melanoma

    • moderate cellularity with small to moderate blood
    • most cells individual
    • round, oval, stellate, spindle shaped
    • cytoplasm:  moderate to abundant that contain granules (brown to green-black)
  53. melanoma in grey horse

    • moderate cellularity with small to moderate blood
    • most cells individual
    • round, oval, stellate, spindle shaped
    • cytoplasm:  moderate to abundant that contain granules (brown to green-black)
  54. mast cell tumor
  55. mast cell tumor
  56. transitional cell tumor

    • cells exfoliate as individuals or in cluster
    • large cells with abundant cytoplasm with cells that have a higher N:C ratio
    • multinucleation
  57. transitional cell carcinoma

    • cells exfoliate as individuals or in clusters
    • large cells with abundant cytoplasm interspersed with cells that have a higher N:C ratio
    • multinucleation is common
  58. transitional cell carcinoma

    • cells exfoliate as individuals or in clusters
    • large cells with abundant cytoplasm are often interspersed with groups of cells that have higher N:C ratio
    • multinucleation is common
  59. histiocytoma

    • slightly larger than neutrophils
    • discrete-cell pattern:  round cell tumor that yields high numbers of small to medium round cells that are individually distributed across the smear
    • moderate amount of plae blue cytoplasm that may stain lighter than the background if a significan amount of proteinaceous background is present
    • if a proteinaceous background is present, cell borders may be difficult to discern
    • nuclei are round/oval/irregular with finely etched, lacy or finely stipples chromatin
    • may contain multiple, small, indistinct nucleoli
  60. histiocytoma

    • slightly larger than neutrophils
    • discrete-cell pattern:  round cell tumor that yields high numbers of small to medium round cells that are individually distributed across the smear
    • moderate amount of pale blue cytoplasm that may stain lighter than the background if a significant amount of proteinaceous backgrount is present
    • if a proteinaceous background is present, cell borders may be difficult to discern
    • nuclei are round/oval/irregular with finely etched, lacy or finely stipples chromatin
    • may contain multiple, small, indistinct nucleoli
  61. plasma cell tumor
  62. mammary gland adenocarcinoma

    • cells occur singly and in clusters
    • round with a round to oval, eccentrically placed nucleus
    • cytoplasm:  variably sized that occasionally contains vacuoles
    • cell borders are indistinct
    • nuclear giant forms may be present
  63. sarcoma
  64. hemangiosarcoma
  65. glandular cell (foam cell)
  66. osteosarcoma

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