NCTI- Pharmacology- Drug List A- Acetylsalicylic Acid

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RunNickMarini
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18385
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NCTI- Pharmacology- Drug List A- Acetylsalicylic Acid
Updated:
2010-05-08 22:08:14
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NCTI Pharmacology Drug List Acetylsalicylic Acid
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NCTI- Pharmacology- Drug List A- Acetylsalicylic Acid
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  1. Acetylsalicylic Acid
    trade name
    • ASA
    • Aspirin
  2. Acetylsalicylic Acid
    class
    • Analgesic
    • Antipyretic
    • Platelet Aggregate Inhibitor
    • NSAID
  3. Acetylsalicylic Acid
    mechanism of action
    • 1. Inhibits aggregation (clumping) of platelets by blocking the formation of the substance thromboxane (A2) ; prolonging bleeding time
    • 2. Provides analgesia by inhibiting prostaglandins and other substances that sensitize pain receptors (blocking of prostaglandins also accounts for the drug’s anti-inflammatory effects).
    • 3. Relieves fever by acting upon the hypothalamic heat regulating center
  4. Acetylsalicylic Acid
    indications
    • 1. Acute myocardial infarction
    • 2. Thrombotic stroke
  5. Acetylsalicylic Acid
    contraindications
    • 1. Active gastrointestinal bleeding
    • 2. Asthma patients with nasal polyps (anaphylaxis is common)
  6. Acetylsalicylic Acid
    side effects
    • Gastrointestinal: bleeding, heartburn, epigastric pain
    • CNS: dizziness, confusion, drowsiness
    • ENT: tinnitus, hearing loss
    • Other: may impair renal function, may prolong labor in pregnancy with increased bleeding
  7. Acetylsalicylic Acid
    precautions
    • 1. Medical history of pre-existing ulcers, liver disease or bleeding disorders
    • 2. Due to the possible association of aspirin with Reye’s syndrome, do not give drug to children or teenagers with signs and symptoms of chickenpox (varicella) without physician consultation
  8. Acetylsalicylic Acid
    interactions
    • 1. inhibits anti-hypertensive effects of ACE inhibitors
    • 2. Ammonium chloride and other urine acidifying drugs will increase effects of aspirin – watch for toxicity
  9. Acetylsalicylic Acid
    routes
    PO
  10. Acetylsalicylic Acid
    onset and duration
    Onset is 5-30 minutes and may last 1-4 hours, peak in 15 min.
  11. Acetylsalicylic Acid
    dosages
    • Adult: 162-325 mg PO
    • Pediatric: not recommended
  12. Acetylsalicylic Acid
    notes
    none

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