NCTI- Pharmacology- Drug List A- Nitroglycerin

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RunNickMarini
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18394
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NCTI- Pharmacology- Drug List A- Nitroglycerin
Updated:
2010-05-08 22:44:32
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NCTI Pharmacology Drug List Nitroglycerin
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NCTI- Pharmacology- Drug List A- Nitroglycerin
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  1. Nitroglycerin
    trade name
    • Nitrolingual
    • Nitrostat
    • Nitrobid
    • Tridil
  2. Nitroglycerin
    class
    • Vasodilator
    • Nitrate
    • Antianginal
  3. Nitroglycerin
    mechanism of action
    • Relaxes smooth muscles causing venous dilation
    • Reduces preload and afterload to the heart
    • Dilates the coronary arteries resulting in increased perfusion of the myocardium
  4. Nitroglycerin
    indications
    • Chest pain of cardiac origin
    • Acute pulmonary edema
  5. Nitroglycerin
    contraindications
    • Blood pressure less than 100 mmHg systolic
    • Patients who have taken Erectile Dysfunction medications in the last 24-48 hours
    • Signs and symptoms of head trauma (increased intracranial pressure) or cerebral hemorrhage
    • Poor systemic perfusion
  6. Nitroglycerin
    side effects
    • Cardiovascular: hypotension, bradycardia, rebound hypertension/tachycardia, palpitations
    • Neurological: headache
    • Other: flushed skin, sublingual burning
  7. Nitroglycerin
    precautions
    Monitor blood pressure closely for signs of hypotension (before and after administration)
  8. Nitroglycerin
    interactions
    Use with caution with patients who already use vasodilators, alcohol, calcium channel blockers, beta blockers and phenothiazides
  9. Nitroglycerin
    routes
    SL, TM (transmucosal), transdermal (nitropaste)
  10. Nitroglycerin
    onset and duration
    Onset in 1-3 minutes and may last 30-60 minutes
  11. Nitroglycerin
    dosages
    • Adult: 0.4 mg as a single spray or single tablet. May repeat every 3-5 minutes
    • Pediatric: not recommended
  12. Nitroglycerin
    notes
    • Do not shake canister if administered as a spray as it will altered the metered dose in a single spray
    • Do not have patient inhale drug on administration as it will alter absorption rate
    • Establish IV prior to or immediately following administration to combat hypotension if necessary

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