ReproHistoFinal5

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Author:
kjschult
ID:
183996
Filename:
ReproHistoFinal5
Updated:
2012-11-16 13:48:30
Tags:
ReproHisto5
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Description:
ReproHisto5
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  1. HSIL of penis
  2. What is this? Is it common? With what is it associated? What is notable about the image? What can we see in the low power image? What is visible in the high power image?

    • Penile invasive squamous cell carcinomaIt is rare (1% of all male malignancies)
    • Associated with: high risk HPV types 16 and 18
    • Notable: squamous epithelium with marked hyperkeratosis and epidermal thickening; under the epidermal layer is the dermal layer characterized by stromal cells and collagen
    • Low power: complete lack of normal maturation in epidermis with no evidence of normal squamous layers; cells are enlarged, hyperchromatic, and have scant cytoplasm
    • High power: the lower edge of the lesion is ragged with irregular infiltrating groups of malignant stromal cells invading the underlying dermis
  3. What is this?
    Penile invasive squamous cell carcinoma
  4. Penile invasive squamous cell carcinoma
  5. Penile invasive squamous cell carcinoma
  6. What do the arrows indicate?
    Squamous pearl in penile invasive squamous cell carcinoma
  7. In what disease is this found (if it's in a male)?
    Penile invasive squamous cell carcinoma

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