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Average onset of MDD?
late 20s but can occur at any age
Does MDD occur in males or females first?
peak onset :
: 55 or older
What is the prevalence of MDD?
Name some risk factors of MDD.
lack of social support
50-60% after first episode
70% after second episode
90% after third episode
Tx for MDD
all ssri's BUT fluvoxamine
fluoxetine place in MDD
good choice for non-compliant pts due to its long half-life. can be useful in pts complaining of fatigue, sedation, or decreased energy
sertraline placement in MDD
fewer drug intxns but requires a dose of 200 mg/day. easier to titrate in geriatrics and patients with anxiety
paroxetine placement for MDD
lease activating and may be better for patients having difficulty sleeping
Citalopram placement in MDD
has reported to produce less sexual dysfunction than other SSRI's (but claim remains unclear!!!)
escitalopram placement in MDD
considered to be no better than citalopram
C/I of bupropion in MDD
seizure disorder, bulimia or anorexia