Micro Test 3: Neisseria
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Micro Test 3: Neisseria
Name the 2 major pathogenic species of Neisseria genus.
Neisseria gonorrhoeae--> gonorrhea and gonococcemia
Neisseria meningitidis-->meningitis and meningococcemia
N. gonorrhoeae= ____ prevalence, ____ mortality
high prevalence, low mortality
N. meningitidis= ____ prevalence, ____ mortality
low prevalence, high mortality
Stiff neck, alertness changes, photophobia, headache are symptoms of
Children with meningitis may demonstrate malaise, decreased food intake, vomiting, lethargy.
Don't confuse this with poop disease!
Neisseria meningitis symptoms develop over how long?
Neisseria meningitidis is cultured on _____ or ______
Chocolate blood agar or Thayer-Martin agar in 5% CO2
Like S. aureus, which other bacteria colonizes the nasopharynx of healthy individuals?
N. mengitidis is postivie for what two enzymes?
Oxidase, and catalase
N. meningitidis virulence factors (5)
1) Polysaccharide capsule- Prevents phagocytosis (A, B, C, Y, W-135 cause 90% of infections)
2) Lipooligosaccharide (LOS)- endotoxin (stimulates inflammatory response/ release of TNFa)
3) Pili- Phase variation
4) PorB proteins
5) Opacity (Opa) Proteins
6) Reduction-modfiable protein (RMP)
7) Transferrin, lactoferrin, and hemoglobin-binding proteins
8) Membrane blebs (contain LOS and surface proteins)
9) IgA1 protease
In addition to phase variation, the pili of N. meningitidis helps the bacteria attach to _____ and resist killing by ____
epithelial cells, neutrophils
Neisseria causes epithelial cell membrane ruffling and induces _______
What N. meningitidis viruelnce factor is an outer membrane protein that facilitates vacterial invasion into epithelial cells?
What N. meningitidis virulence factor is an outer membrane protein that helps bacteria bind to epithelial cells?
Opacity (Opa) proteins
N. meningitidis virulence factor that is an outer membrane protein. IgG and IgA1 antibodies directed against RMPs interfere with bactericidal action of antibodies directed against LOS.
Reduction-modifiable protein (RMP)
N. meningitis virulence factor that contains LOS and surface proteins. It enhances endotoxin-mediated toxicity and protects bacterial cells from antibodies.
What bacteria can cause subsequent hearing deficits, learning deficits, and arthritis?
Septicemia (w/ or w/o meningitis)
Petecheial skin lesions coalesce into larger hemorrhagic lesions
DIC w/ shock
Name 2 host defenses against Neisseria.
Anti-type specific antibodies
Menincococci can inactivate complement by blocking the formation of _____
Complement deficiencies lead to icnrease risk of
The conjugate vaccine (MCV4) for meningococcemia is based on the ________ . It is recommended for ______.
Capsular polysaccharide, preadolescence
Which serogroup of infection causing Neisseria is there no vaccine for?
How do you treat N. meningitidis?
Penicillin (drug of choice)
Immunoprophylaxis for N. meningitidis consists of?
Besides meningitis, N. meningitidis can cause (3 things)
How is N. meningitidis spread? What are the natural hosts?
Human are only natural hosts (most common in 16-21 y/o's)
Spread by aerosolized secretions from respiratory tract.
Name 2 Neisseria species that are commensals in the oropharynx.
4. Colonizes human _______
3. Facultative Anaerobe
4. oropharynx (like N. sicca & N. mucosa)
Most commonly isolated from human bite wounds or fistfight injuries.
Subacute Endocarditis: HACEK
Haemophilus (parainfluenzae, aphrophilus, paraphrophilus)
How do you treat Eikenella corrodens?
Susceptible to penicilin, ampicillin, cephalosporins, tetracyclines, and fluoroquinolones.
Which bacteria corrodes/ creates indentions when grown on blood agar?
Name the 4 bacteria that colonize the human oropharynx.
Which bacteria causes septic arthritis in children? What is its shape?
Kingella kingae (Gram-N coccobacillus)
Which bacteria is a commensal in the human respiratory tract?
What is the 3rd leading cause of otitis media in young children?
M. catarrhalis resembles _____ in culture and causes exacerbations in _____
Which bacteria causes exacerbations in COPD?
M. catarrhalis virulence factors (3)
Biofilm (important in otitis media)