Micro Test 3: Neisseria

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Micro Test 3: Neisseria
2012-11-16 17:14:49

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  1. Neisseria:
    1)  Gram-P/N
    2)  Shape
    3)  Motile?
    4)  Aerobe/Nonaerobe
    5)  Oxidase-P/N
    • 1)  Gram-N
    • 2)  Diplococci
    • 3)  Non-motile
    • 4)  Aerobic
    • 5)  Oxidase-P
  2. Name the 2 major pathogenic species of Neisseria genus.
    • Neisseria gonorrhoeae--> gonorrhea and gonococcemia
    • Neisseria meningitidis-->meningitis and meningococcemia
  3. N. gonorrhoeae= ____ prevalence, ____ mortality
    high prevalence, low mortality
  4. N. meningitidis= ____ prevalence, ____ mortality
    low prevalence, high mortality
  5. Stiff neck, alertness changes, photophobia, headache are symptoms of
  6. Children with meningitis may demonstrate malaise, decreased food intake, vomiting, lethargy. 
    Don't confuse this with poop disease!
  7. Neisseria meningitis symptoms develop over how long?
    1-4 days
  8. Neisseria meningitidis is cultured on _____ or ______
    Chocolate blood agar or Thayer-Martin agar in 5% CO2
  9. Like S. aureus, which other bacteria colonizes the nasopharynx of healthy individuals?
    Neisseria meningitidis
  10. N. mengitidis is postivie for what two enzymes?
    Oxidase, and catalase
  11. N. meningitidis virulence factors (5)
    • 1) Polysaccharide capsule- Prevents phagocytosis (A, B, C, Y, W-135 cause 90% of infections)
    • 2) Lipooligosaccharide (LOS)- endotoxin (stimulates inflammatory response/ release of TNFa)
    • 3) Pili- Phase variation
    • 4) PorB proteins
    • 5)  Opacity (Opa) Proteins
    • 6)  Reduction-modfiable protein (RMP)
    • 7)  Transferrin, lactoferrin, and hemoglobin-binding proteins
    • 8)  Membrane blebs (contain LOS and surface proteins)
    • 9)  IgA1 protease
  12. In addition to phase variation, the pili of N. meningitidis helps the bacteria attach to _____ and resist killing by ____
    epithelial cells, neutrophils
  13. Neisseria causes epithelial cell membrane ruffling and induces _______
    actin polymerization
  14. What N. meningitidis viruelnce factor is an outer membrane protein that facilitates vacterial invasion into epithelial cells?
  15. What N. meningitidis virulence factor is an outer membrane protein that helps bacteria bind to epithelial cells?
    Opacity (Opa) proteins
  16. N. meningitidis virulence factor that is an outer membrane protein.  IgG and IgA1 antibodies directed against RMPs interfere with bactericidal action of antibodies directed against LOS.
    Reduction-modifiable protein (RMP)
  17. N. meningitis virulence factor that contains LOS and surface proteins.  It enhances endotoxin-mediated toxicity and protects bacterial cells from antibodies.
    Membrane blebs
  18. What bacteria can cause subsequent hearing deficits, learning deficits, and arthritis?
    N. meningitidis
  19. Septicemia (w/ or w/o meningitis)
    Multiorgan involvement
    Petecheial skin lesions coalesce into larger hemorrhagic lesions
    DIC w/ shock
  20. Name 2 host defenses against Neisseria.
    • Anti-type specific antibodies
    • Complement activity
  21. Menincococci can inactivate complement by blocking the formation of _____
    C5b-9 complex
  22. Complement deficiencies lead to icnrease risk of
  23. The conjugate vaccine (MCV4) for meningococcemia is based on the ________ .  It is recommended for ______.
    Capsular polysaccharide, preadolescence
  24. Which serogroup of infection causing Neisseria is there no vaccine for?
  25. How do you treat N. meningitidis?
    • Penicillin (drug of choice)
    •        Cephalosporins
  26. Immunoprophylaxis for N. meningitidis consists of?
  27. Besides meningitis, N. meningitidis can cause (3 things)
    • Pharyngitis
    • Pneumonia
    • Urethritis
  28. How is N. meningitidis spread?  What are the natural hosts?
    • Human are only natural hosts (most common in 16-21 y/o's)
    • Spread by aerosolized secretions from respiratory tract.
  29. Name 2 Neisseria species that are commensals in the oropharynx.
    • N. sicca
    • N. mucosa
  30. Eikenella Corrodens:
    1.  Gram-P/N
    2.  Shape
    3.  Aerobe/Anaerobe
    4.  Colonizes human _______
    • 1.  Gram-N
    • 2.  Rod
    • 3.  Facultative Anaerobe
    • 4.  oropharynx (like N. sicca & N. mucosa)
  31. Most commonly isolated from human bite wounds or fistfight injuries.
    Eikenella corrodens
  32. Subacute Endocarditis:  HACEK
    • Haemophilus (parainfluenzae, aphrophilus, paraphrophilus)
    • Actinobacillus
    • Cardiobacterium hominis
    • Eikenella corrodens
    • Kingella kingae
  33. How do you treat Eikenella corrodens?
    Susceptible to penicilin, ampicillin, cephalosporins, tetracyclines, and fluoroquinolones.
  34. Which bacteria corrodes/ creates indentions when grown on blood agar?
    Eikenella corrodens
  35. Name the 4 bacteria that colonize the human oropharynx.
    • N. sicca
    • N. mucosa
    • Eikenella corrodens
    • Kingella kingae
  36. Which bacteria causes septic arthritis in children?  What is its shape?
    Kingella kingae (Gram-N coccobacillus)
  37. Which bacteria is a commensal in the human respiratory tract?
    Moraxella catarrhalis
  38. Moraxella catarrhalis
    1)  Gram-P/N
    2)  Shape
    3)  Aerobe/Anaerobe
    4)  Oxidase-P/N
    • 1)  Gram-N
    • 2)  Diplococci
    • 3)  Aerobic
    • 4)  Oxidase-P
  39. What is the 3rd leading cause of otitis media in young children?
    Moraxella catarrhalis
  40. M. catarrhalis resembles _____ in culture and causes exacerbations in _____
    Neisseria, COPD
  41. Which bacteria causes exacerbations in COPD?
    M. catarrhalis
  42. M. catarrhalis virulence factors (3)
    • Adhesins
    • Inactivates complement
    • Biofilm (important in otitis media)