Pediatric Terminology

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Author:
Anonymous
ID:
184129
Filename:
Pediatric Terminology
Updated:
2012-11-17 17:06:17
Tags:
Empey
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Description:
Female empey
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  1. Gestational age
    conception to birth
  2. postnatal age
    birth to present
  3. postconceptual age
    gestational age + postnatal age
  4. postmenstrual age
    gestational age + postnatal age
  5. neonate
    birth to 1 month
  6. infant
    1 month to 1 year
  7. child
    1-12 years
  8. adolescent
    13-18 years
  9. Pediatric Absorption (11)
    • neutral ph at birth (premies more basic, reaches 1-2 by 2-7 yrs)
    • delayed gastric empying
    • decreased intestinal motility
    • unpredictable GI peristalsis
    • immature intestinal mucosa (inc permeabiity)
    • immature biliary function (dec absorption of lipophilic)
    • higher levels of beta-glucuronidase
    • frequent feeding
    • needs to be palatable
    • frequent pooping
  10. Rule of thumb with Vd and hydro and lipophilic drugs
    • larger doses of hydrophilic
    • smaller doses of hydrophobic
  11. protein binding in neonates and infants
    lower protein concentrations - drugs that are highly protein bound have a higher free fraction than they would in adults
  12. BBB
    structurally mature at 20 weeks postconception, but still more permeable to small lipid insoluble
  13. Phase I metabolism
    • CYP450 50% adult activity at birth (adult activity by 3-6 mo)
    • metabolism in some CYP450s passes adults
  14. Phase II metabolism
    • Sulfation - well developed
    • acetylation - adult levels at 1 mo
    • glycination - adult levels at 6 mo
    • glucuronidation - adult levels at 1-2 yrs
  15. Renal elimination
    TS slower to develop than GF

    matures rapidly 

    lower doses of renally cleared drugs during first week of life, then inc
  16. Creatinine cls Schwartz eqn
  17. SE K value premature <1 yr
    0.33
  18. SE K value full term <1 yr
    0.45
  19. SE K value 2-12 yrs
    0.55
  20. SE K value 12-21 yrs female
    0.55
  21. SE K value 12-21 yrs Male
    0.70

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