- classification- Therapeutic: antidiabetics
- Pharmacologic: sulfonylureas
indications for use- Control of blood glucose in type 2 diabetes mellitus when diet therapy fails. Require some pancreatic function.
action- Lower blood glucose by stimulating the release of insulin from the pancreas and increasing the sensitivity to insulin at receptor sites. May also decrease hepatic glucose production. Therapeutic effects: lowering of blood glucose in diabetic patients.
contraindications/precautions- Hypersensitivity; hypersensitivity with sulfonamides, type 1diabetics; diabetic coma or ketoacidosis, concurrent use of bosentan.
Life-threatening adverse reactions/most common side effects for each medication- CNS: dizziness, drowsiness, headache, weakness GI: constipation, cramps, diarrhea, drug induced hepatitis, heartburn, increased appetite, nausea, vomiting DERM: photosensitivity, rashes. ENDO: hypoglycemia F and E: hyponatremia Hemat: aplastic anemia, argranulocytosis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia