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This drug category interacts with ergosterols in fungal membranes to form artificial "pores." Resistant fungal strains appear to have low ergosterol content in their cell membranes.
Name the category and some examples.
- Polyenes include:
- Amphotericin B
Explain the activity and Clinical Uses of:
- Amphotericin B has a wide fungicidal spectrum. It is the Drug of Choice for severe infections caused by:
- Aspergillus, Candida, Cryptococcus, Histoplasma, Mucor, and Sporothrix
- We use Amphotericin B with flucytosine in candidiasis and cryptococcoses because of synergistic effects, and because of high toxicity of Amphotericin B.
What is the DOC (drug of choice) for Aspergillus, Candida, Cryptococcus, Histoplasma, Mucor and Sporothrix?
Why do we not use Nystatin for systemic use?
It is too toxic, we use it topically.
How do we take Amphotericin B?
- Slow IV infusion, so the patients must be in hospital.
- Amphotericin has poor penetratuib into CNS so
- It is one of the only drugs that we use intrathecally (introduced into or occurring in the space under the arachnoid membrane of the brain or spinal cord.)