NCTI- Pharmacology- Drug List B- Naloxone

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Author:
RunNickMarini
ID:
18448
Filename:
NCTI- Pharmacology- Drug List B- Naloxone
Updated:
2010-05-09 12:59:00
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NCTI Pharmacology Drug List Naloxone
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NCTI- Pharmacology- Drug List B- Naloxone
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  1. Naloxone
    trade name
    Narcan
  2. Naloxone
    class
    Narcotic (Opiate) Antagonist
  3. Naloxone
    mechanism of action
    Reverses the respiratory depression and CNS sedation of narcotics by competing for opiate receptor sites in the brain
  4. Naloxone
    indications
    Known or suspected narcotic overdoses with inadequate respiratory function
  5. Naloxone
    contraindications
    none
  6. Naloxone
    side effects
    • Cardiovascular: tachycardia, hypertension, dysrhythmias
    • Neurological: tremors/seizures, aggressive/combative
    • Gastrointestinal: nausea/vomiting
  7. Naloxone
    precautions
    • Give drug prior to intubation
    • Prepare to protect patient and EMS personnel due to aggressive/combative personality following rapid reversal of a narcotic overdose
    • Does not reverse narcotic-induced hypotension
    • Use with caution in narcotic addicts or chronic pain patients, as Narcan will rapidly reverse the CNS depressant effects of opiods.
  8. Naloxone
    interactions
    none
  9. Naloxone
    routes
    IV, IO, IM, IN, ET
  10. Naloxone
    onset and durations
    Immediate onset when administered IV/IO/IN/ET and 5-10 minutes if administered IM. Either may last 20-30 minutes
  11. Naloxone
    dosages
    Adult: 1.0 – 2.0 mg IV/IM or 2.0 – 4.0 mg ET. Titrate IV dose toadequate respiratory rate and tidal volume. May repeat dose every 5 minutes as needed

    Pediatric: 0.1 mg/kg IV/IM or 0.2 mg/kg ET. Titrate IV dose toadequate respiratory rate and tidal volume. May repeat dose every 5 minutes as needed
  12. Naloxone
    notes
    Darvon and other synthetic narcotics may require larger dosages to reverse the effects

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