NCTI- Pharmacology- Drug List B- Dextrose 50% in water (D50W)

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RunNickMarini
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18454
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NCTI- Pharmacology- Drug List B- Dextrose 50% in water (D50W)
Updated:
2010-05-09 13:09:45
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NCTI Pharmacology Drug List Dextrose water D50W
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NCTI- Pharmacology- Drug List B- Dextrose 50% in water (D50W)
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  1. Dextrose 50% in water (D50W)
    trade name
    25 gm of Dextrose in a 50 ml solution
  2. Dextrose 50% in water (D50W)
    class
    carbohydrate
  3. Dextrose 50% in water (D50W)
    mechanism of action
    Provides immediate source of glucose for cellular metabolism
  4. Dextrose 50% in water (D50W)
    indications
    ALOC due to documented or suspected hypoglycemia
  5. Dextrose 50% in water (D50W)
    contraindications
    • There are no absolute contraindications to the IV administration of dextrose in the emergency setting
    • Relative contraindication: Use with caution in patients with increasing Intracranial pressure as the added glucose may worsen the cerebral edema.
  6. Dextrose 50% in water (D50W)
    side effects
    • Patients may complain of warmth, pain or burning at the injection site.
    • Dextrose can cause severe neurologic symptoms (Wernicke’s encephalopathy or Korsakoff’s psychosis) if patient is thiamine deficient.
  7. Dextrose 50% in water (D50W)
    precautions
    • Aspirate prior to administration and after every 10-15 ml to ensure IV patency (medication will cause necrosis)
    • Cannulate largest vein possible and run IV wide open prior to and after administration
    • Relative contraindication: Use with caution in patients with increasing intracranial pressure as the added glucose may worsen the cerebral edema or potentiate cellular necrosis in hemorrhagic stroke
  8. Dextrose 50% in water (D50W)
    interactions
    none
  9. Dextrose 50% in water (D50W)
    routes
    IVP, IO
  10. Dextrose 50% in water (D50W)
    onset and duration
    Onset will be 30-60 seconds but duration depends upon degree and cause of hypoglycemia
  11. Dextrose 50% in water (D50W)
    dosages
    Adult: 25 gm (50 ml solution preload) IVP/IOMay repeat once in 5 minutes

    Pediatric: Birth – 1 month: 0.5g-1gm/kg (5-10 ml/kg) slow IVP of a 10% solution. May repeat once in 10 minutes.

    1 month+-2 years: 0.5g-1gm/kg (2-4 ml/kg) slow IVP/IO of a 25% solutionMay repeat once in 5 minutes

    Over 2 years: 0.5g-1gm/kg (1-2 ml/kg) slow IVP/IO of a 50% solution (same solution as for the adult)May repeat once in 5 minutes
  12. Dextrose 50% in water (D50W)
    notes
    Do not exceed a 12.5% concentration in neonates.

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