microbiology unit 3 exam

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  1. Acquire Immunity Fig. Breaks down into 2---2
    Image Upload
  2. What is an antigen? And what's their chemical nature?
    Substance against which the immune response occurs. Proteins and carbohydrates
  3. Antigenic Determinants (___________) are a specific....
    (epitopes) ....part of antigen targeted by immune response.
  4. What do antigenic determinants produce when recognized?
    surface receptors that will bind to it. 
  5. What involves various types of T cells?
    Cell Mediated Immunity (CMI)
  6. What are TH? Example?
    What are TC? Example?
    • T helper cells. Ex. CD4+
    • T cytotoxic cells. Ex. CD8+
  7. What is the initiation of CMI? Which is what type of cell?
    Antigen Presentation. Antigen Presenting Cells (APSs)-Macrophages and dendritic cells.
  8. What is the job of antigen presentation?
    • phagocytize and digest antigen. Fragments(potentialADs) are displayed on cell surface and bound to a MHC protein.
    • T cells bind to displayed ADs.
  9. What does the TH cells bind to? Which then cause the activated TH cells to.....
    • MHCII plus AD displayed on APC.
    •    Undergo cell division. Large popluations of cells targeted to antigen proven to be a threat. –Several active types of TH cells and memory TH
    •    Secrete cytokines. 
  10. Cytokines are....
    required for activation of TC , B cells and several other types of cells.
  11. What is the activation requirements for the CTL response?
    –TCs bind to MHC-I plus AD displayed on APC

    –Cytokines from activated TH cells
  12. What is the activation requirements for the CTL response?
    •Activation Results

    –Cell division

    • •Larger population of activated cells (CTL’s) targeted
    • to current threat.

  13. Humoral Immunity....
    • •B cells become programmed to respond to a particular antigenic
    • determinant.

    • –Produce proteins called antibodies (immunoglobulins) that
    • specifically bind to that antigenic determinant.
  14. T-Dependent B Cell reponse
    –B cell is activated

    • •Cell division creates a large population of B cells
    • that target this AD

    –Some form the memory for this AD

    • –Some become plasma cells that secrete antibodies
    • targeted to this AD
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    •B cell binds to antigen and presents AD.

    •TH binds to presented AD and secretes  cytokines.
  16. Actions of Antibodies
    • •Effects of antibodies binding to their ADs.  (formation of antigen-antibody
    • complexes) 

    –complement activation (classical pathway)

    • –opsonization (Fc region binds to
    • phagocytes)

    • –agglutination (inactivation &/or increased
    • efficiency of phagocytosis)

    –neutralization (toxins, viruses)

    –antibody-dependent cell-mediated cytotoxicity

    –*know the bold words in the next slide*
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  18. What are memory cells? What do they do...?
    • - large pool of cells programmed for this AD -
    • some can immediately become plasma cells
    • –rapid increase in titer prevents significant increase
    • in number of microbes so no illness 
  19. **explain why we don’t get sick after initial
    •Antibody Kinetics

    • –Primary Response - first exposure
    • to AD

    • •7 - 10 days for rise in titer due
    • to time needed for T and B cells to proliferate

    • –time for microbe to grow and
    • disease symptoms to appear

    Secondary (Anamnestic) Response - subsequent exposure to AD
  20. TH and TC memory cells are also produced...
    This allows...
    during primary reponse. rapid response by these cells to subsequent infections.

Card Set Information

microbiology unit 3 exam
2012-11-20 15:08:13

Chap 17 Adaptive immunity Lucier @ ACC fall 2012
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