Mechanisms of pathology

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Author:
lngray82
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184766
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Mechanisms of pathology
Updated:
2012-11-26 20:49:47
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micro
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exam 3
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  1. The ability to cause disease
    pathogenicity
  2. the extent of pathogenicity
    virulence
  3. mucous membranes, skin,parenteral route, and preferred portal are all example of
    portals of entry
  4. infectious dose for 50% of the test population is
    ID50
  5. Lethal dose (of toxin) for 50% of the test population is
    LD50
  6. These three things Glycocalyx, fimbriae and m protein help an organism to do what?
    Adherence or attach to the host so they are infecious and also form biofilms
  7. Thi sprotein helps sticks or adheres and also resist phagocytotosis
    M protein, this is a cell wall component
  8. This protein inhibits T helper cells
    Opa protein, this is a cell wall component
  9. This is a waxy lipid that resists digestion
    mycolic acid, this is a cell wall component
  10. Coagulates fibrinogen
    coagulase
  11. Digest fibrin clots
    Kinases (fibrinolysin)
  12. Hydrolyzes hyaluronic acid
    hyaluronidase
  13. hydrolyzes collagen
    collagenase
  14. destroys igA antibodies
    igA proteases
  15. This is where a bacteria alters the hosts actin (skeleton of cell wall) to enter a host cell
    invasion
  16. these use ________ to move from one cell to the next
    actin
  17. Substance that contributes to pathogenicity?
    Toxin
  18. The ability to produce a toxin
    toxigenicity
  19. The presence of toxin in the host's blood
    toxemia
  20. The inactivated toxin used in a vaccine
    toxoid
  21. Antibodies against a specific toxin is called?
    Antitoxin
  22. Neurotoxin, enterotoxin and cytotoxins are examples of what?
    toxins...just effect different parts of the body
  23. exotoxins are secreted where?
    outside the cell, they exit out
  24. gram + form what kind of toxins?
    exotoxins
  25. explain what the a-b exotoxin B stand for?
    B is for binding wher eit attaches to the hosts receptor
  26. What does the A do in a-b exotoxins?
    It alters cell functio by inhibiting protein synthesis
  27. Some exotoxins do not enter the host cell but go in through poking holes by making protein channels in the plasma
    membrane-disrupting exotoxins
  28. Very potent exotoxins are called?
    Superantigens
  29. These cause an intense immune response due to release of cytokines from host cells and symptoms include fever, nausea,vomiting diarrhea shock and death
    superantigens
  30. The exotoxin in corynebacterium diphtheriae is?
    A-B toxin
  31. The toxin in Streptococcus pyogenes is?
    Membrane-disrupting erythrogenic toxin
  32. The toxin in closttridium botulinum is
    A-B toxin: neurotoxin
  33. The toxin in C. tetani is?
    A-B toxin: neurotoxin
  34. The toxin in Vibrio chloerae is?
    A-B toxin: enterotoxin
  35. What toxin is in Staphlococcus aureus?
    Superantigen
  36. Toxic shock syndrome is due to what antigen>?
    superantigen
  37. Endotoxin are part of what of the cell?
    The cell wall in gram neg
  38. The only organisms that can have endotoxins are?
    gram neg
  39. Lipid A is?
    a toxin released from a gram neg organism
  40. In gram neg endotoxins release large amounts when a cell????? and small amts when a cell????
    dies,:::divides

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