Calcium Channel Blockers

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Author:
CharlieSCC
ID:
185219
Filename:
Calcium Channel Blockers
Updated:
2012-11-24 23:56:11
Tags:
Calcium Channel Blockers antagonists antihypertensives antianginal antiarrythmic class IV
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Description:
Calcium channel blockers
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  1. Calcium Channel Blockers

    diltiazem  -  Cardizem
    nifedipine  -  Procardia, Adalat
    verapamil  -  Calan, Isoptin
    nicardipine  -  Cardene

    MOA 
    • Blocks the calcium channel in VSM (vascular smooth muscle)
    •      - calcium increases muscle contractility, peripheral resistance, and BP
    •      - inhibits the transport of calcium into the myocardial and VSM cells resulting in inhibition of excitation-contraction coupling and cond contraction
    •      - Systemic vasodilation - decreased BP

    Coronary vasodilation - decreased frequency and severity of angina

    decrease ventricular rate in atrial fibrillation

    Large central arteries are not as sensitive to calcium blockers as coronary and cerebral arteries and peripheral vessels

    highly protien bound

    short half life
  2. Calcium Channel Blockers

    diltiazem  -  Cardizem
    nifedipine  -  Procardia, Adalat
    verapamil  -  Calan, Isoptin
    nicardipine  -  Cardene

    SE
    diltiazem - Cardizem: peripheral edema

    HA, flushing, peripheral edema
  3. Calcium Channel Blockers

    diltiazem  -  Cardizem
    nifedipine  -  Procardia, Adalat
    verapamil  -  Calan, Isoptin
    nicardipine  -  Cardene

    Contraindication
    pedi, geri, OB, lactation
  4. Calcium Channel Blockers

    names?
    • diltiazem  -  Cardizem
    • nifedipine  -  Procardia, Adalat
    • verapamil  -  Calan, Isoptin
    • nicardipine  -  Cardene

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