- Classification- Therapeutic: anti-multiple sclerosis agents, immune modifiers
- Pharmacologic: interferons
Indications- Relapsing forms of multiple sclerosis
Action- Antiviral and immunoregulatory properties produced by interacting with specific receptor sites on cell surfaces may explain beneficial effects produced by recombinant DNA technology. Therapeutic: reduce incidence of relapse (neurologic dysfunction) and slow physical disability.
Contraindications/precautions- Hypersensitivity to natural or recombinant interferon beta or human albumin. Use cautiously in history of suicde attempt or depression; history of seizures, cardiovascular disease, liver disease, history of alcohol abuse, patients with childbearing potential OB: may increase risk of spontaneous abortion; use only if potential maternal benefit outweighs potential fetal risk LACTATION: safety not established PEDI: safety not established.
Life threatening adverse reactions/most common side effects- CNS: seizures increasaed with interferon beta-1A, depression, dizziness, fatigue, headache, insomnia, drowsiness, incoordination, rigors, suicidal ideation EENT: sinusitis, vision abnormalities. RESP: dyspnea, upper respiratory tract infection. CV: chest pain, edema, hypertension GI: constipation, nausea, vomiting, abdominal pain, auto immune hepatitis, dry mouth, elevated liver function tests GU: cystitis, erectile dysfunction, polyuria, urinary incontinence. Derm: rashes, alopecia, EDNO: menstrual disorders, hyperthyroidism, hypothyroidism, menorrhagia, spontaneous abortion HEMAT: neutropenia, anemia, eosinophilia, thrombocytopenia LOCAL: injection site reactions, injection site necrosis MS: myalgia, arthralgia, muscle spasm MISC: allergic reactions including ANAPHYLAXIS, chills, fever, flue like symptoms, pain.