med chem quiz 9

Card Set Information

Author:
tab
ID:
185428
Filename:
med chem quiz 9
Updated:
2012-12-09 12:51:35
Tags:
quiz anti viral
Folders:

Description:
quiz 9 anti-viral
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user tab on FreezingBlue Flashcards. What would you like to do?


  1. obligate cellular parasites composed of nucleic acid core and a pretein outer shell
    viruses
  2. which viruses cause polio, colds, pneumonia, gastroenteritis, influenza, hepatitis, encephalitis, yellow fever, hemorrhagic fever, rubela, mumps, rabies, AIDS, Ebola
    RNA
  3. which viruses cause cold sores, conjunctivitis, genital herpes, encephalitis, shingles, chickenpox, mononucleosis, hepatitis, small pox, warts, URI
    DNA
  4. the most successful prophylaxis against viral disease
    immunization
  5. what is the biggest problem with trying to get a vaccine for a virus
    rapid viral mutation
  6. what must vaccines be to provide a response
    sufficiently antigenic
  7. most common viral infection
    cytomegalovirus
  8. virus most humans  are exposed to
    epstein-barr virus
  9. virus characterized by chicken pox
    herpes varicell-zoster virus
  10. virus characterized by blisters and lesions
    herpes simplex
  11. phosphonate anti-herpes agent
    indicated for acyclovir resistant HSV-1&2 and varicella Zoster
    injection - not a cure
    watch for renal impairment
    selective inhibition of pyrophosphate bonding site - specific DNA polymerase
    foscarnet sodium - foscavir
  12. synthetic nucleoside anti-herpes agent
    HSV-1&2
    epstein-barr
    oral, IV or topical
    inhibits DNA polymerase and replication by being incorporated into DNA
    dosage based on Creatinine clearance
    acyclovir - zivirax
  13. prodrug form of the drug acyclovir
    oral use only with rapid first-pass deesterification
    valacyclovir HCL - valtrex
  14. synthetic nucleoside anti-herpes agent
    only for use in CMV infections in immuno-compormised or transplant patients
    known teratogenic - catergory C
    MOA - 2 mechanisms, complete inhibition of DNA polymerase, DNA incorporation resulting in DNA chain termination
    take with food
    dose based on Crcl
    ganciclovir - cytovene
  15. synthetic nucleoside anti-herpes agent
    ophthalmic implant
    vitrasert
  16. synthetic nucleoside anti-herpes agent
    indicated for immunocompromised patients (not liver transplant)
    prodrug ester of ganciclovir
    MOA - 2 mechanisms - competitive inhibition of DNA polymerase, DNA incorporation resulting in DNA chain termination
    valganciclovir HCL - valcyte
  17. synthetic nucleoside anti-herpes agent
    ind - herpes labialis
    moa - inhibits DNA polymerase following phosphorylation to the triphosphate
    topical cream
    peniciclovir - denavir
  18. synthetic nucleoside anti-herpes agent
    ind - acute herpes zoster, genital herpes
    prodrug form of penicilovir
    oral use only
    moa- inhibits DNA polymerase following phosphorylation to the triphosphate
    can be taken without regard to meals
    famciclovir - famvir
  19. synthetic nucleoside anti-herpes agent
    ind - patients that have failed ganciclovir or fascarnet
    injection only, must be co-administered with probenecid
    moa- inhibits DNA polymerase following phosphorylation to the diphosphate
    class C
    cidofovir - vistide
  20. anti-herpes agent for oral and facial herpes simplex cold sores and lesions
    10% cream for topical application
    moa - inhibits viral replication of a number of lipid enveloped viruses
    docosanol - abreva
  21. anti-sense anti-herpes agent
    ind - CMV retinitis in immunocompormised patients
    moa - antisense oligonucleotide
    intravitreal injection only 
    no longer available in the USA
    fomivirsen sodium - vitravene
  22. synthetic nucleoside topical opthalmic anti-viral
    known as IDU
    ind - herpes simplex keratitis
    moa - resembles thymidine, incorporated into a pseudostructure
    don't use with boric acid solutions, sensitivity to light
    idoxuridine - dendrid, herplex
  23. synthetic nucleoside topical anti-viral
    ind - keratoconjunctivitis
    moa - interfers with DNA synthesis, not exactly known
    stinging upon administration
    trifluridine - viroptic
  24. synthetic nucleoside topical ophthalmic anti-viral
    ointment
    discontinued in the USA
    vidarabine - vira-A
  25. anti-RSV
    lyophillized powder for aerosol inhalation
    infants and young children
    accumulates in red cells
    teratogenic
    virazole
  26. anti-RSV agent
    safety and efficacy has NOT been established for treatmetn of RSV disease
    blocks a critical step in membrane fusion process
    palivizumab - synagis
  27. treatment for Hep A
    rest and avoid alcohol
  28. phosphonate nucleotide analog of adenosine used for HBV & HIV
    moa - prodrug that inhibits HBV DNA polymerase
    adefovit dipivoxil - hepsera
  29. unmodified beta-L enantiomer of thymidine
    HBV for 16 yo and up
    no known activity against HIV
    competitve inhibition of thymidine 5'-triphosphate
    telbivudine - tyzeka
  30. guanosine nucleotide
    inhibits all three activities of HBV
    no clinically relvant activity against HIV-1
    must be taken on an empty stomach
    entecavir - baraclude
  31. peptidomimetic for HCV
    used in combination with peginterferon and ribavirin
    compensated liver disease
    moa inhibits serine protease
    take with high fat meal
    telaprevir - incivek
  32. peptidomimetic for HCV
    used in combination with peginterferon and ribavirin
    compensated liver disease
    moa inhibits serine protease
    take with high/low fat meal
    boceprevir - victrelis
  33. anti-influenza agent
    prophylaxis against influenza A
    moa- uncoating
    renally excreted
    amantadine HCL - symmetrel
  34. anti-influenza agent
    prophylaxis against influenza A
    moa- uncoating
    metabolized by the liver
    prodrug substrate for p-glycoprotein not the substrate
    rimantadine HCL - flumadine
  35. anit-influenza neuraminidase inhibitor
    influenza A & B, symptomatic for less than 2 days
    drug of choice in avian H5N1
    moa - ethyl ester prodrug alters particle aggregation and release
    oseltamivir phosphate - tamiflu
  36. anit-influenza neuraminidase inhibitor
    influenza A & B, symptomatic for less than 2 days
    useful in avian H5N1
    moa - ethyl ester prodrug alters particle aggregation and release
    zanamivir - relenza
  37. cleavage of this, by neuramidase facilitates the spread of new virus and increases pathogenicity
    sialic acid
  38. IV only for H1N1
    peramivir

What would you like to do?

Home > Flashcards > Print Preview