NCTI- Pharmacology- Drug List C- Mannitol

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Author:
RunNickMarini
ID:
18556
Filename:
NCTI- Pharmacology- Drug List C- Mannitol
Updated:
2010-05-09 23:23:27
Tags:
NCTI Pharmacology Drug List Mannitol
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Description:
NCTI- Pharmacology- Drug List C- Mannitol
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  1. Mannitol
    trade name
    Osmitrol
  2. Mannitol
    class
    osmotic diuretic
  3. Mannitol
    mechanism of action
    • Inhibits sodium and water absorption in the kidneys
    • Promotes fluid movement from the intracellular into the extracellular space
    • Dehydrates brain tissue to decrease ICP
  4. Mannitol
    indications
    • Acute cerebral edema
    • Blood transfusion reactions
  5. Mannitol
    contraindications
    • Acute pulmonary edema
    • Severe pulmonary congestion
    • Hypovolemia
  6. Mannitol
    side effects
    • Cardiovascular: chest pain
    • Neurological: mental status change
  7. Mannitol
    precautions
    • May cause transient increase in intravascular volume
    • May cause CHF
    • May cause sodium depletion (hyponatremia)
    • Will crystallize in low temperatures
    • Should be used with in-line filters
  8. Mannitol
    interactions
    Should not be administered during blood transfusions
  9. Mannitol
    routes
    IV, IO, IVPB
  10. Mannitol
    onset and duration
    Onset in 15 minutes to reduce ICP, 1-3 hours for diuresis; may last 3-8 hours
  11. Mannitol
    dosages
    • Adult: 1.5 – 2 gm/kg slow IVPB/IV
    • Pediatric: 0.25 – 0.5 gm/kg over 60 minutes
  12. Mannitol
    notes
    none

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