NCTI- Pharmacology- Drug List C- Dopamine

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RunNickMarini
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18557
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NCTI- Pharmacology- Drug List C- Dopamine
Updated:
2010-05-09 23:31:08
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NCTI Pharmacology Drug List Dopamine
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NCTI- Pharmacology- Drug List C- Dopamine
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  1. Dopamine
    trade name
    Intropin
  2. Dopamine
    class
    • Sympathomimetic
    • Catecholamine
    • Vasopressor
  3. Dopamine
    mechanism of action
    • Low Dose or Renal/Mesenteric Dose (1-5 mcg/kg/min):
    • Dilates renal and mesenteric arteries by stimulating dopaminergic receptors
    • May decrease blood pressure due to vasodilation
    • Increases urinary output

    • Moderate Dose or Inotropic Dose (5-10 mcg/kg/min):
    • Increases inotropy without increasing chronotropy
    • Increases blood pressure by stimulating the beta1 receptors

    • High Dose or Vasopressor Dose (10-20 mcg/kg/min):
    • Causes vasoconstriction
    • Increase inotropy and chronotropy
    • Increases blood pressure by stimulating the alpha and beta1 receptors
  4. Dopamine
    indications
    • Cardiogenic shock
    • Distributive shock after fluids
    • Hemodynamically significant hypotension
    • Symptomatic bradycardia (second line drug)
  5. Dopamine
    contraindications
    • Hypovolemia
    • Tachydysrhythmias
  6. Dopamine
    side effects
    • Cardiovascular: tachycardia, hypertension/hypotension, chest pain, ventricular irritability
    • Respiratory: dyspnea
  7. Dopamine
    precautions
    • Cannulate largest vein possible and ensure IV patency (necrotic)
    • Start a second IV line if additional medications are needed (Dopamine infusion should not be interrupted to ensure adequate therapeutic blood levels)
  8. Dopamine
    interactions
    • Flush tubing before and after administration of Sodium Bicarbonate as Dopamine will be inactivated by the change in pH
    • Actions may be intensified if patient is also taking antidepressants
    • May cause hypotension if patient taking phenytoin (Dilantinīƒĸ)
  9. Dopamine
    routes
    IVPB
  10. Dopamine
    onset and duration
    Onset in 5 minutes and will last 3-5 minutes
  11. Dopamine
    dosages
    • Adult: Add 400 mg into 250 ml Normal Saline solution (creating1600 mcg/ml solution)
    • Low dose: 1-5 mcg/kg/min
    • Moderate dose: 5-10 mcg/kg/min
    • High dose: 10-20 mcg/kg/min

    • Pediatric: Add 400 mg into 250 ml Normal Saline solution (creating1600 mcg/ml solution)
    • Low dose: 1-5 mcg/kg/min
    • Moderate dose: 5-10 mcg/kg/min
    • High dose: 10-20 mcg/kg/min
  12. Dopamine
    notes
    • Flow rate determines which receptor sites are stimulated and results in a graded response
    • Frequent vital signs are required for all patients with a Dopamine infusion
    • Once appropriate blood pressure is achieved, infusion may need to be slowed but should not be stopped

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