Med Chem Virus

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Author:
75ford
ID:
185790
Filename:
Med Chem Virus
Updated:
2012-11-27 22:17:31
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Med Chem Virus
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Description:
Med Chem Virus
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  1. Foscarnet/Foscavir
    • Anti-herpes (Phosphate)
    • Very toxic to kidneys
    • Inhibiits DNA rep.
  2. Acyclovir/Zovirax
    • Synthetic nucleoside
    • triphosphate inhibits DNA
    • Class B pregnancy
  3. Valacyclovir/Valtrex
    • Prodrug of acyclovir
    • Oral only
  4. Ganciclovir/Cytovene
    • Synthetic nucleoside
    • used for cytomeg. in pt with immuno comp.
    • Very toxic
  5. Valgaciclovir/Valcyte
    • Synthetic nucleoside
    • CMV in immuno comp and transplant pt. (not liver trans)
    • Plasma levels similar to IV Ganciclovir
  6. Penciclovir/Denavir
    Topical Cream
  7. Famciclovir/Famvir
    Prodrug oral form of Penciclovir
  8. Cidofovir/Vistide
    • For pt that failed with ganciclovir
    • Injection only, must be administered with probenecid
  9. Abreva
    • Cream for oral and facial herpes
    • MOA inhibits viral replication
  10. Vitravene
    • Removed from the market
    • Anti-sense technology
    • Injected into the eyeball
  11. Idoxuridine/Dendrid
    MOA resembles thymidine, incorperates into DNA making pseudostructures.
  12. Trifluridine/Viroptic
    Opthalmic, keratoconjunctavitis
  13. Vidarabine/Vira-A
    • Topical Opthalmic
    • Discontinued in US
  14. Ribavirin
    • Anti RSV agent
    • Only in ICU
    • Only for kids
  15. Synagis
    • Anti RSV
    • IM injection
    • Safety and efficacy not established
  16. Ribavirin+interferon/Copegus
    Used to treat Hepatitis
  17. Adefovir/Hepsera
    • Hep B
    • Adenosine analog (prodrug)
    • Prevents DNA polymerase
  18. Telbivudine/Tyzeka
    • Thymidine analog
    • Chronic Hep B 16yrs old+
    • No activity against HIV
    • Lactic acidosis
  19. Entecavir/Baraclude
    • guanosine analog (Hep B)
    • Very Potent
  20. Telaprevir/Incivek
    • Hep C
    • Diet is very important (New 2011)
    • Take with 20g of fat
  21. Boceprevir/Victrelis
    • Hep C
    • Take with food
  22. Amantadine/Symmetrel
    • Anti-Influenza
    • Treat Parkinsons from CO poisining
  23. Ramantadine/Flumadine
    Anti-Flu
  24. Oseltamivir/Tamiflu
    • Anti-Flu neuraminidase inhibitor
    • Drug of choice for avian flu
    • Can lead to mental instability
  25. Zanamivir/Relenza
    • Anti-flu
    • Inhaled powder
    • Do not use in pt with pulmonary disease

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