BioChem Pentose Phosphate Pathway

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Author:
bradley.knox
ID:
185880
Filename:
BioChem Pentose Phosphate Pathway
Updated:
2012-11-29 17:40:04
Tags:
PPP
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Description:
PPP
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  1. What are the two other names for PPP?
    • Hexose Monphosphate Shunt
    • 6-Phosphogluconate Pathway
  2. What are the main purposes of PPP?
    • Provide NADPH
    • Produce ribose-5-phosphate
    • Metabolic mechanism of 5-carbon sugars
  3. How many ATP are consumed or produced from PPP?
    Zero
  4. How many NADPH are produced for each G-6-P?
    2
  5. 3 carbons = ?
    4 carbons = ?
    5 carbons = ?
    6 carbons = ?
    7 carbons = ?
    9 carbons = ?
    • 3 = Trioses (glyceraldehyde)
    • 4 = tetroses (erythrose)
    • 5 = pentoses (ribose)
    • 6 = hexoses (glucose)
    • 7 = heptoses (sedoheptulose)
    • 9 = nonoses (neuraminic acid)
  6. In what part of the cell does PPP occur?
    cytoplasm
  7. How many irreversable reactions are in PPP?
    2
  8. What is the primary regulaton of PPP?
    • glucose-6-phosphate --> 6-phosphogluconolactone
    • inhibited by NADHP
  9. How many carbons are moved by Transketolase and what does it require?
    • 2 Carbons
    • Thiamine pyrophosphate
  10. How many carbons are moved by transaldolase?
    3 carbons
  11. What enzyme is used to convert G6P to 6-phosphogluconolactone?
    glucose-6-phosphate degydrogenase
  12. What enzyme converts 6-phosphogluconolactone to 6-phosphogluconate?
    gluconolactonase (6-phosphogluconolactone hydrolase)
  13. What enzyme converts 6-phosphogluconate to ribulose-5-phosphate?
    6-phosphogluconate dehydrogenase
  14. What steps produce NADPH?
    • Step1 G-6-P to 6-phosphogluconolactone
    • Step3 6-phosphogluconate to ribulose-5-phosphate
  15. What are the two primary functions of NADPH?
    • Fatty acid synthesis
    • Reduction of glutathione (prevents oxidative damage)

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