BioChem Pentose Phosphate Pathway
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What are the two other names for PPP?
- Hexose Monphosphate Shunt
- 6-Phosphogluconate Pathway
What are the main purposes of PPP?
- Provide NADPH
- Produce ribose-5-phosphate
- Metabolic mechanism of 5-carbon sugars
How many ATP are consumed or produced from PPP?
How many NADPH are produced for each G-6-P?
3 carbons = ?
4 carbons = ?
5 carbons = ?
6 carbons = ?
7 carbons = ?
9 carbons = ?
- 3 = Trioses (glyceraldehyde)
- 4 = tetroses (erythrose)
- 5 = pentoses (ribose)
- 6 = hexoses (glucose)
- 7 = heptoses (sedoheptulose)
- 9 = nonoses (neuraminic acid)
In what part of the cell does PPP occur?
How many irreversable reactions are in PPP?
What is the primary regulaton of PPP?
- glucose-6-phosphate --> 6-phosphogluconolactone
- inhibited by NADHP
How many carbons are moved by Transketolase and what does it require?
- 2 Carbons
- Thiamine pyrophosphate
How many carbons are moved by transaldolase?
What enzyme is used to convert G6P to 6-phosphogluconolactone?
What enzyme converts 6-phosphogluconolactone to 6-phosphogluconate?
gluconolactonase (6-phosphogluconolactone hydrolase)
What enzyme converts 6-phosphogluconate to ribulose-5-phosphate?
What steps produce NADPH?
- Step1 G-6-P to 6-phosphogluconolactone
- Step3 6-phosphogluconate to ribulose-5-phosphate
What are the two primary functions of NADPH?
- Fatty acid synthesis
- Reduction of glutathione (prevents oxidative damage)
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