Card Set Information
SnSs of childlhood leukemia?
Tx for leukemia?
Allogeneic (stem cell) BMT
What are the most important factors in determining outcomes for CNS tumors?
1) success of resection
2) ability to tx across blood/brain barrier.
(Radiation, although improved, is still devestating especially to children.)
SnSs for non-Hodgkin's Lymphoma
Tumor Lysis Syndrome
Superior Vena-Cava Syndrome
Tx for non-Hodgkin's Lymphoma?
Prevention & Treatment of Hyperuricemia #1 Priority
Response often very rapid to induction chemotherapy
What is Hodgkin's Disease?
Tumor Lysis issues rare
Prognosis depends on stage/histology
Systemic chemotherapy replacing XRT
Follow-Up for Late Effects vital!
T/F: Amputation is the gold standard Tx for Osteosarcoma and Ewing's Sarcoma.
: Used to be true, but new procedures have made amputation the exception, not the rule, and limbs are salvaged whenever possible.
Both still require agressive chemo.
What is a neuroblastoma?
Tumor of sympathetic nervous tissue
Common sites include adrenal gland, mediastinum, liver
Bone involvement = poor outcome
Infants < 12 months often have spontaneous regression of tumor
SnSs for Neuroblastoma?
Tx for Neuroblastoma?
HD Chemo with PBSC’s (Periferal Blood Stem Cells)
Infants < 12 mos with Stage IV-S receive no therapy
What is Wilm's Tumor?
Primary tumor of the kidney
Patients often appear well except for palpable mass
Outcome generally good, even in metastatic cases unless unfavorable histology
Chemotherapy often curative without radiation
What is a rabdomyosarcoma?
Tumor involving muscle cell precursors
Where do pts usually express Germ Cell Tumors?
(usually accompanied by
What is included in a workup for a pt with cancer who is showing neutorpenia and fever?
CBC w/manual diff
Broad-Spectrum Antibiotics X 48 hours minimum
What is the greatest risk of toxicity for oncology pts?
• Greatest risk is for bacteria to get out of where they “belong” and enter the blood stream:
– Staph (skin)
– Alpha Strep (Throat)
– Gram neg’s (GI)
When do you start thinking blood transfusion in an oncology pt?
Generally, Transfuse When Hgb < 8.0 (< 10 if Patient is Receiving Radiation Therapy)
Infuse slowly over 3-4 hrs.
When does thrombocytopenia get scary?
When platelet count <50k.
Infuse between 30-60 minutes as fast as pt can tolerate.
What is stomatitis?
Stomach's response to chemo/radiation toxicity, ie:
Where does stomatitis occur?
Breakdown of mucosal lining of:
Tx with multiple Rx depending on symptoms/locations
What is most commonly used to treat n/v related to chemo/radation?
(neither cases distonia, hallucinations, or sedation)
What is most important to remember with a patient with constipation issues related to chemo/radiation?
NOTHING PER RECTUM!
What are some SnSs of renal toxicity in a pt undergoing chemo/radiation?
Colored Urine When Drug Excreted
• Decreased GFR
• Decreased drug excretion
What do you do to Tx pancreatic toxicity in the patient undergoing chem/radation?
Treatment is Symptomatic & Supportive (“Pseudo-Diabetes”)
Monitor status by assessment of amylase/lipase