Thyroid-Pharm

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Author:
arh3321
ID:
186599
Filename:
Thyroid-Pharm
Updated:
2012-12-02 15:32:36
Tags:
Pharm
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Description:
Jakes a lazy fuck
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  1. Hypothyroidism
    High TSH and low T3 and T4

    Cold, Pale, Puffy, overweight, lethargy, decrease HR and T, cold intolerance

    can cause myxedma, and cretinism (kids-MR and growth failure)
  2. Hyperthyroidism
    Low TSH high T3 and T4

    often caused by Graves disease

    can cause thyrotoxic crisis if under extreme stress (surgery, infection ect.)- very high fever, tachycardia, coma, HF
  3. Tx for Hypothyroidism
    Liothyronine (Cytomel)- T3 faster than levothyroxine but shorter hlaf life

    Levothyroxine (Synthroid, Levithroid, Levoxyl)- t4 that converts to t3 in body

    ADR: rare if overdose=hyperthyroidism symptoms

    Interactions: many, warfarin-increases=bleeding

    take in am on empty stomach-take for life
  4. Tx of Hyperthyroidism
    • blocks t4, t3
    • Propylthiouracil (PTU)-ADRS: agranuloctyosis, hypothyroidism, can use in preggos
    • Methimazole (Tapazole)- longer half life, dont use in pregnancy, slower onset
  5. Propranolol (Inderal)
    • use for hyperthyroidism and throtoxic crisis- to decrease HR
    • non selective beta blocker
    • dont effect t3 or t4

    ADRs: Bronchoconstriction- concern w/asthma
  6. Glucocorticoids ADRS
    • Adrenal suppression (if stopped abruptly)
    • Growth retardation in kids
    • Cataracts/glaucoma
    • Peptic Ulcer disease
    • Cushings syndrome
    • osteoporosis
    • Hyperglycemia
    • Leukocysosis
  7. Acute adrenal insufficiency/ Adrenal Crisis
    • D/t abrupt withdrawl of long term tx (>10 days)-taper
    • can be d/t addison's disease

    risks: hypoglycemia, and cardiocadcular collapse
  8. Osteoporosis
    Tx with Bisphonates: Alendronate (Fosamax), Risedronate (Actonel)

    • ADRs: esophagitis- if cant sit or stand 30 mins dont give ,
    • Musculoskeletal pain, jaw necrosis, bone fx

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