Rickettsia, Ehrlichia, Orientia, Anaplasma, and Coxiella are all
obligate intracellular parasites
Name 5 obligate intracellular parasites
Rickettsia, Ehrlichia, Orientia, Anaplasma, and Coxiella
What organism causes Lyme disease?
Borrelia burgdorferi (Gram-N spirochete)
What organism causes Rocky Mountain Spotted Fever?
What two organisms are transmitted by body lice, and thus have a solely human reservoir?
Borrelia recurrentis, R. prowazekki(epidemic typhus), R. quintana (trench fever)
What drug/class works very well on these diseases?
Name 3 spirochete disease agents
Borrelia causes Lyme disease which is characterized by
Not usually visible with conventional light microscopy
Most common tickborne illness in N. America and Europe
Lyme Disease, caused by Borrelia burgdorferi
Difficul to grow in vitro
Few proteins in outer sheath, most of those are lipoproteins which are potent activators of innate immunity via TLRs
When is lyme disease most commonly diagnosed? Which forms of tick are most commonly the transmitters of lyme disease?
Most commonly diagnosed in june/july (summer). Nymph and larva are most likely to cause disease because they are smaller and thus harder to feel on you. They must be on you 36-48 hours before you get lyme disease.
Characteristic expanding (bulls-eye) rash at site of tick bite in 60-80% of patients is called _____ and is diagnostic of?
Erythema migrans, Lyme disease
Early Localized Lyme Disease presents with?
Cure rate at this stage?