Skeletal Muscle Bioenergetics I

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Author:
marysham
ID:
186749
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Skeletal Muscle Bioenergetics I
Updated:
2012-12-03 12:29:03
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  1. What are key metabolic features of skeletal muscle? (4)
    • 1. Metabolic plasticity
    • 2. Mitochondrial enrichment
    • 3. Major site of insulin-responsive glucose uptake/metabolism (GLUT 4)
    • 4. Muscle-specific isoforms of several metabolic enzymes.
  2. What can be described as a dynamic structure with extraordinary adaptive potential (metabolic and contractile properties)?
    Skeletal myofibers.
  3. What are the phenotypic profiles of muscles affected by? (5)
    • 1. Innervation/neuromuscular activity
    • 2. Exercise training
    • 3. Mechanical loading/unloading
    • 4. Hormones
    • 5. Aging
  4. How many molecules of ADP are reused to resnthesize ATP? What is the byproduct? What, then, is activated?
    2 ADP --> ATP + AMP

    AMP activates AMPK. 
  5. What is harmful about the buildup of lactate under anaerobic settings?
    Buildup of lactate can lower blood pH leading to serious consequences. 

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