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DBB Exam 3 - Marijuana
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Pharmacokinetics of marijuana
Intoxication peaks quickly (10-30 mins)
Half-life
: 20-30 hours
High concentrations of CB1 receptors in which brain regions?
Basal ganglia
Cerebellum
Hippocampus
Dentate gyrus
Cortex
CB1 receptor is ionotropic or metabotropic?
Metabotropic (G-protein)
Endocannabinoids
Anandamide and 2-AG
Lipid soluble
CB1 receptors are typically located on (pre-/post-) synaptic neurons
Pre- (on axon terminals)
Endocannabinoids and retrograde signaling
Endocannabinoids synthesized in post-, then go from post- to pre- and inhibit both GABA and glutamate release (book only says GABA)
What do endocannabinoids do?
Regulation of food and energy balance
Regulation of reward systems
Analgesia
Cell proliferation
Cell protection
Immune responses
Endocrine/cardiovascular functions
CB1 vs CB2 receptors
CB1
: in CNS
CB2
: Spleen and immune cells
Overactivity of endocannabinoid system
Increased food intake, obesity, etc...
Rimonobant
CB1 antagonist
Original goal to decrease food consumption, leading to weight loss
Problem
: severe psychiatric side effects
Rimnobant and marijuana
Rimnobant decreases high from marijuana
Currently available prescription cannabinoid medications
Nabinol (similar to delta-9-THC)
Marinol (delta-9-THC)
Sativex
THC and cannabidiol
Treatment of MS
Cannabidiol and CB1 receptor
Cannabidiol does not influence CB1 receptor
Author
jdwein39
ID
186979
Card Set
DBB Exam 3 - Marijuana
Description
asdf
Updated
12/4/2012, 4:28:24 AM
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