DBB Exam 3 - Marijuana

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DBB Exam 3 - Marijuana
2012-12-03 23:28:24
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  1. Pharmacokinetics of marijuana
    • Intoxication peaks quickly (10-30 mins)
    • Half-life: 20-30 hours
  2. High concentrations of CB1 receptors in which brain regions?
    • Basal ganglia
    • Cerebellum
    • Hippocampus
    • Dentate gyrus
    • Cortex
  3. CB1 receptor is ionotropic or metabotropic?
    Metabotropic (G-protein)
  4. Endocannabinoids
    • Anandamide and 2-AG
    • Lipid soluble
  5. CB1 receptors are typically located on (pre-/post-) synaptic neurons
    Pre- (on axon terminals)
  6. Endocannabinoids and retrograde signaling
    Endocannabinoids synthesized in post-, then go from post- to pre- and inhibit both GABA and glutamate release (book only says GABA)
  7. What do endocannabinoids do?
    • Regulation of food and energy balance
    • Regulation of reward systems
    • Analgesia
    • Cell proliferation
    • Cell protection
    • Immune responses
    • Endocrine/cardiovascular functions
  8. CB1 vs CB2 receptors
    • CB1: in CNS
    • CB2: Spleen and immune cells
  9. Overactivity of endocannabinoid system
    Increased food intake, obesity, etc...
  10. Rimonobant
    • CB1 antagonist
    • Original goal to decrease food consumption, leading to weight loss
    • Problem: severe psychiatric side effects
  11. Rimnobant and marijuana
    Rimnobant decreases high from marijuana
  12. Currently available prescription cannabinoid medications
    • Nabinol (similar to delta-9-THC)
    • Marinol (delta-9-THC)
  13. Sativex
    • THC and cannabidiol
    • Treatment of MS
  14. Cannabidiol and CB1 receptor
    Cannabidiol does not influence CB1 receptor