DBB Exam 3 - Marijuana

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Pharmacokinetics of marijuana
- Intoxication peaks quickly (10-30 mins)
- Half-life: 20-30 hours
High concentrations of CB1 receptors in which brain regions?
- Basal ganglia
- Cerebellum
- Hippocampus
- Dentate gyrus
- Cortex
CB1 receptor is ionotropic or metabotropic?

Metabotropic (G-protein)
Endocannabinoids
- Anandamide and 2-AG
- Lipid soluble
CB1 receptors are typically located on (pre-/post-) synaptic neurons

Pre- (on axon terminals)
Endocannabinoids and retrograde signaling

Endocannabinoids synthesized in post-, then go from post- to pre- and inhibit both GABA and glutamate release (book only says GABA)
What do endocannabinoids do?
- Regulation of food and energy balance
- Regulation of reward systems
- Analgesia
- Cell proliferation
- Cell protection
- Immune responses
- Endocrine/cardiovascular functions
CB1 vs CB2 receptors
- CB1: in CNS
- CB2: Spleen and immune cells
Overactivity of endocannabinoid system

Increased food intake, obesity, etc...
Rimonobant
- CB1 antagonist
- Original goal to decrease food consumption, leading to weight loss
- Problem: severe psychiatric side effects
Rimnobant and marijuana

Rimnobant decreases high from marijuana
Currently available prescription cannabinoid medications
- Nabinol (similar to delta-9-THC)
- Marinol (delta-9-THC)
Sativex
- THC and cannabidiol
- Treatment of MS
Cannabidiol and CB1 receptor

Cannabidiol does not influence CB1 receptor