2 organisms living together in varoious relationships
commensalism vs mutualism vs parasitism
one benefits, neither harmed
both benefit
one benefits, other harmed
final host
host where parasite gains sexual maturity
reservoir host
organism infected with a parasite that also infects humans
pathogen
any parasitic organism that causes infectious disease
primary vs opportunistic pathogen
primary causes disease by direct interaction with healthy host
opportunistic is part of normal flora and caueses disease when it gains access to a place it shoudn't be
pathogenicity
ability of a parasite to cause disease
immunopathology
ability to trigger exaggerated immune responses
factors impacting host parasite relationships
# of organisms
degree of virulence of pathogen
host's defense
the intensity of a pathogen is deteremined by
infectivity- ability to esablish focal point of infection
invasiveness - ability to spread to adjacent tissues
pathogenic potential - degree to which pathogen can damage host
LD50 and ID50
number of pathogens that kill 50% of a group of hosts in a specified time
same but infect not kill
how to bacterial pathogens gain acess to host
actively penetrate host's mucous membranes or skin or passivly penetrate through wounds or opening in skin
how to bacteria spread through tissue
producing specific products or enzymes
bacteremia
viable bacteria in blood
septicemia
bacteria or their toxins in blood
intracellular pathogens
bacteria that are able to grow and multiply in various cells of a host
facultative intracellular pathogens
can live within host cells and in the outside environment
obligate intracellular pathogens
can't grow/multiply outside of a host
pathogenicity islands
increase virulence is coded in large segments of DNA that carry virulence genes which alllows for things like e. coli to inject virulence proteins into cytoplasm of eucaryotics hosts
intoxications
disease that result from a specific toxin produced by bacteria
toxemia
condition caused by toxins in the blood of host
toxin
specific substance that damages host
exotoxins
usually released as the pathogen grows
a soluble protein
travels to other tissues to where it causes damge
cause antibody produciton (can be bad_
AB exotoxins
A subunit is repsonsible for toxic effect
B subunit binds to target cell
superantigens
produce and extrmeem immune respononse from the host
interotoxins:
target intestinal mucosa
cytotoxins
target generall tissues
pore forming exotoxins
membrane distrupting exotoxin that can cause hemolytic reactions and kill the cell
beta and alpha hemolysis
beta is complete lysis and alpha is partial
phospholipase enzymes
remove charged head groups from phospholipids in host cell plasma membranes which destabilizes the membrane so the cell lyses and dies
endotoxins
toxins bound to bacterium
released when organism lyses
lipid A toxic component
weaker than exotoxins
systematic effects of endotoxins
fever
shock
blood cogulations
weakness
diarrhea
(all effects are indirect)
host primary defenses
limiting bacteria entry while still remaining functional
i.e. skin, mucocus membranes with cillia, ph reg
secondary defenses for host
soluble anti-microbial producst
host blood and other body fluids contain anti-microbials