Micro Test 3: Parasites of Immunosuppressed
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Name 3 species of free living amoeba
- Naegleria fowleria
- Acanthamoeba sp.
- Leptomyxi amebae
Parasites of Immunosuppressed (3)
- Toxoplasma gondi
- Pneumocystis (carinii) jirovecci
- Microsporidia sp.
Free living amoeba type not seen in humans
Free living amoeba type seen in humans
Two stages of Acanthamoeba
- Cysts- environmentally resistant, diagnostic stage
- Trophozoites- infective and diagnostic
How do acanthamoeba trophozoites replicate?
What ameba when in inhaled leads to granulomatous emebic enccephalitis (GAE)?
Acathamoeba (enters CNS via hematogenous spread)
Are acanthamoeba cysts and trophozoites found in tissues?
N. fowferi is found in thermal discharges of power plants
3 Stages in life cycle of N. fowferi
- Cysts (environmentally resistant)- not in brain tissue
- Trophozoites (infective and diagnostic)- CSF and tissue
- Flagellated forms (temporarily non-feeding forms)- CSF
N. fowferi trophozoites infect humans by penetrating the _______ and migrating to the ______ via the _________. This leads to ____________.
- nasal mucosa
- olfactory nerve
- Primary Amebic Meningoencephalitis (PAM)
Type of encephalitis:
- Acanthameoba- Granulomatous amebic encephalitis (GAE)
- N. fowferi- Primary Amebic Meningoencephalitis (PAM)
An acute suppurative infection of the brain and meninges that is rapidly fatal and usually diagnosed ante-mortum.
Primary Amebic Meningoencephalitis (PAM)
- Caused by Naegleria spp.
- AmpB (not really effective)
GAE/PAM: Which one is a more slowly progressive, chronic disease associated with environmental exposures?
- Acanthamoeba or Leptomyxic amebae
GAE/PAM: cysts with wrinkled-walls
Ring inflitrate of cornea (yellow eye)
Definitive hosts of Toxoplasma gondii
cats (family Felidae)
What stage of Toxoplasma gondii forms the reservoirs fo infective tissue cysts?
Non-motile bradyzoite stage
What stage of Toxoplasma gondii exhibits asexual reproduction?
Motil tachyzoite disease producing stage
+ IgM titer in serum of newborn
Asymptomatic Congenital Toxo (ACT)
Disseminated infection may exist in AIDS pts w/o demonstrable titer
Serologic Diagnosis of Toxo-1
Fungus causing significant opportunistic infections in immunosuppressed/immunocompromised patients, most common life threatening infection of AIDS patients in US before HAART (Highly Active Anti-Retroviral Therapy)
Pneumocystic (carinii) jirovecii
Thickened alveolar wwalls and alveoli filled with "foamy" eosinophilic exudate
Microsporidia develop by _____ to mature spores
sporongy...is that even a real word?
What would you like to do?
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