What are the mucosal protective agents?
Sucralfate - give 1 hour before meal at least. Do not give until at least 30 minutes before PPI or H2 antagonist administration as sucralfate needs acid pH.
Bismuth like agents - similar to sucralfate but also may inhibit pepsin and stimulate mucus and bicarb productin. Also antibacterial and active against H. Pylori. Combine with antibiotics, ulcer healing rates up to 98%
Misoprostol (prostaglandin E1 analog) - inhibits gastric acid secretion. Prevents ulcers in patients on chronic NSAIDS. Short t1/2 so requires multiple daily dosing.