Mendelian Genetics III: Multiple Alleles

a.    Why is it dominant?
i.    Alleles are simply variations in __
1.    When dominant coexists with recessive in heterozygote, they don’t interact
a.    It is in the __that come into play

b.    For any character, the observed dominant/ recessive relationship of alleles depends on level of phenotype examination:
Ex:

i.    Tay-Sachs
1.    Brain cells of kid cannot __ due to malfunctioned crucial enzyme
a.    Lipids accumulate in __-->__-->__--> degeneration of motor and mental performance

2.    Only kids who inherit two copies of __ have it
a.    At organismal level: __
b.    Activity level of lipid-metabolizing enzyme is __between for heterozygous
i.    Biochemical level: __
c.    Molecular level: normal allele and Tay-Sachs allele are __
i.    Equal numbers of normal and dysfunctional enzyme molecules

True or False: Dominant Alleles are always more popular than recessive gene

c.    Multiple Alleles
i.    Most genes occur in more than __allelic forms
1.    ABO blood groups: __alleles
a.    Blood group (__) may be one of four types
i.    A and B refer to two __on surface of RBCs
ii.    Neither is O

d.    Pleiotrophy
i.    Most genes have multiple phenotypic effects= __
1.    Responsible for multiple symptoms associated with certain hereditary diseases